Background: The TNF family ligand EDA1 is required for development of hair, teeth, and many glands. Results: Mouse fetuses exposed to anti-EDA antibodies develop a permanent ectodermal dysplasia. Conclusion: Monoclonal anti-EDA antibodies block EDA at stoichiometric ratio in vitro and in vivo. Significance: Down-modulation of EDA has useful research and potentially therapeutic applications.
|Number of pages||13|
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 14 Feb 2014|