Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia

Christine Kowalczyk-Quintas; Laure Willen; Anh Thu Dang; Heidi Sarrasin; Aubry Tardivel; Katharina Hermes; Holm Schneider; Olivier Gaide; Olivier Donzé; Neil Kirby; Denis J. Headon; Pascal Schneider

doi:10.1074/jbc.M113.535740

Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia

Christine Kowalczyk-Quintas, Laure Willen, Anh Thu Dang, Heidi Sarrasin, Aubry Tardivel, Katharina Hermes, Holm Schneider, Olivier Gaide, Olivier Donzé, Neil Kirby, Denis J. Headon, Pascal Schneider

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

Background: The TNF family ligand EDA1 is required for development of hair, teeth, and many glands. Results: Mouse fetuses exposed to anti-EDA antibodies develop a permanent ectodermal dysplasia. Conclusion: Monoclonal anti-EDA antibodies block EDA at stoichiometric ratio in vitro and in vivo. Significance: Down-modulation of EDA has useful research and potentially therapeutic applications.

Original language	English
Pages (from-to)	4273-4285
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.535740
Publication status	Published - 14 Feb 2014
Externally published	Yes

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Kowalczyk-Quintas, C., Willen, L., Dang, A. T., Sarrasin, H., Tardivel, A., Hermes, K., Schneider, H., Gaide, O., Donzé, O., Kirby, N., Headon, D. J., & Schneider, P. (2014). Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia. Journal of Biological Chemistry, 289(7), 4273-4285. https://doi.org/10.1074/jbc.M113.535740

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title = "Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia",

abstract = "Background: The TNF family ligand EDA1 is required for development of hair, teeth, and many glands. Results: Mouse fetuses exposed to anti-EDA antibodies develop a permanent ectodermal dysplasia. Conclusion: Monoclonal anti-EDA antibodies block EDA at stoichiometric ratio in vitro and in vivo. Significance: Down-modulation of EDA has useful research and potentially therapeutic applications.",

author = "Christine Kowalczyk-Quintas and Laure Willen and Dang, {Anh Thu} and Heidi Sarrasin and Aubry Tardivel and Katharina Hermes and Holm Schneider and Olivier Gaide and Olivier Donz{\'e} and Neil Kirby and Headon, {Denis J.} and Pascal Schneider",

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doi = "10.1074/jbc.M113.535740",

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Kowalczyk-Quintas, C, Willen, L, Dang, AT, Sarrasin, H, Tardivel, A, Hermes, K, Schneider, H, Gaide, O, Donzé, O, Kirby, N, Headon, DJ & Schneider, P 2014, 'Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia', Journal of Biological Chemistry, vol. 289, no. 7, pp. 4273-4285. https://doi.org/10.1074/jbc.M113.535740

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T1 - Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia

AU - Kowalczyk-Quintas, Christine

AU - Willen, Laure

AU - Dang, Anh Thu

AU - Sarrasin, Heidi

AU - Tardivel, Aubry

AU - Hermes, Katharina

AU - Schneider, Holm

AU - Gaide, Olivier

AU - Donzé, Olivier

AU - Kirby, Neil

AU - Headon, Denis J.

AU - Schneider, Pascal

PY - 2014/2/14

Y1 - 2014/2/14

N2 - Background: The TNF family ligand EDA1 is required for development of hair, teeth, and many glands. Results: Mouse fetuses exposed to anti-EDA antibodies develop a permanent ectodermal dysplasia. Conclusion: Monoclonal anti-EDA antibodies block EDA at stoichiometric ratio in vitro and in vivo. Significance: Down-modulation of EDA has useful research and potentially therapeutic applications.

AB - Background: The TNF family ligand EDA1 is required for development of hair, teeth, and many glands. Results: Mouse fetuses exposed to anti-EDA antibodies develop a permanent ectodermal dysplasia. Conclusion: Monoclonal anti-EDA antibodies block EDA at stoichiometric ratio in vitro and in vivo. Significance: Down-modulation of EDA has useful research and potentially therapeutic applications.

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IS - 7

ER -

Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia

Abstract

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