Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia

Christine Kowalczyk-Quintas, Laure Willen, Anh Thu Dang, Heidi Sarrasin, Aubry Tardivel, Katharina Hermes, Holm Schneider, Olivier Gaide, Olivier Donzé, Neil Kirby, Denis J. Headon, Pascal Schneider

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25 Citations (Scopus)

Abstract

Background: The TNF family ligand EDA1 is required for development of hair, teeth, and many glands. Results: Mouse fetuses exposed to anti-EDA antibodies develop a permanent ectodermal dysplasia. Conclusion: Monoclonal anti-EDA antibodies block EDA at stoichiometric ratio in vitro and in vivo. Significance: Down-modulation of EDA has useful research and potentially therapeutic applications.

Original languageEnglish
Pages (from-to)4273-4285
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
Publication statusPublished - 14 Feb 2014
Externally publishedYes

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