Generating iPSCs: Translating cell reprogramming science into scalable and robust biomanufacturing strategies

Marli Silva; Laurence Daheron; Hannah Hurley; Kim Bure; Richard Barker; Andrew J. Carr; David Williams; Hae Won Kim; Anna French; Pete J. Coffey; Justin J. Cooper-White; Brock Reeve; Mahendra S Rao; Evan Y. Snyder; Kelvin S. Ng; Benjamin E. Mead; James A. Smith; Jeffrey M. Karp; David A. Brindley; Ivan Wall

doi:10.1016/j.stem.2014.12.013

Generating iPSCs: Translating cell reprogramming science into scalable and robust biomanufacturing strategies

Marli Silva, Laurence Daheron, Hannah Hurley, Kim Bure, Richard Barker, Andrew J. Carr, David Williams, Hae Won Kim, Anna French, Pete J. Coffey, Justin J. Cooper-White, Brock Reeve, Mahendra S Rao, Evan Y. Snyder, Kelvin S. Ng, Benjamin E. Mead, James A. Smith, Jeffrey M. Karp, David A. Brindley, Ivan Wall

Research output: Contribution to journal › Review Article › Other › peer-review

58 Citations (Scopus)

Abstract

Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21^st century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Cell Stem Cell
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2014.12.013
Publication status	Published - 8 Jan 2015
Externally published	Yes

Access to Document

10.1016/j.stem.2014.12.013

Cite this

Silva, M., Daheron, L., Hurley, H., Bure, K., Barker, R., Carr, A. J., Williams, D., Kim, H. W., French, A., Coffey, P. J., Cooper-White, J. J., Reeve, B., Rao, M. S., Snyder, E. Y., Ng, K. S., Mead, B. E., Smith, J. A., Karp, J. M., Brindley, D. A., & Wall, I. (2015). Generating iPSCs: Translating cell reprogramming science into scalable and robust biomanufacturing strategies. Cell Stem Cell, 16(1), 13-17. https://doi.org/10.1016/j.stem.2014.12.013

@article{0bba8fef4aa04d1dbdac0d702452e696,

title = "Generating iPSCs: Translating cell reprogramming science into scalable and robust biomanufacturing strategies",

abstract = "Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21st century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.",

author = "Marli Silva and Laurence Daheron and Hannah Hurley and Kim Bure and Richard Barker and Carr, \{Andrew J.\} and David Williams and Kim, \{Hae Won\} and Anna French and Coffey, \{Pete J.\} and Cooper-White, \{Justin J.\} and Brock Reeve and Rao, \{Mahendra S\} and Snyder, \{Evan Y.\} and Ng, \{Kelvin S.\} and Mead, \{Benjamin E.\} and Smith, \{James A.\} and Karp, \{Jeffrey M.\} and Brindley, \{David A.\} and Ivan Wall",

year = "2015",

month = jan,

day = "8",

doi = "10.1016/j.stem.2014.12.013",

language = "English",

volume = "16",

pages = "13--17",

journal = "Cell Stem Cell",

issn = "1934-5909",

publisher = "Elsevier",

number = "1",

}

Silva, M, Daheron, L, Hurley, H, Bure, K, Barker, R, Carr, AJ, Williams, D, Kim, HW, French, A, Coffey, PJ, Cooper-White, JJ, Reeve, B, Rao, MS, Snyder, EY, Ng, KS, Mead, BE, Smith, JA, Karp, JM, Brindley, DA & Wall, I 2015, 'Generating iPSCs: Translating cell reprogramming science into scalable and robust biomanufacturing strategies', Cell Stem Cell, vol. 16, no. 1, pp. 13-17. https://doi.org/10.1016/j.stem.2014.12.013

TY - JOUR

T1 - Generating iPSCs

T2 - Translating cell reprogramming science into scalable and robust biomanufacturing strategies

AU - Silva, Marli

AU - Daheron, Laurence

AU - Hurley, Hannah

AU - Bure, Kim

AU - Barker, Richard

AU - Carr, Andrew J.

AU - Williams, David

AU - Kim, Hae Won

AU - French, Anna

AU - Coffey, Pete J.

AU - Cooper-White, Justin J.

AU - Reeve, Brock

AU - Rao, Mahendra S

AU - Snyder, Evan Y.

AU - Ng, Kelvin S.

AU - Mead, Benjamin E.

AU - Smith, James A.

AU - Karp, Jeffrey M.

AU - Brindley, David A.

AU - Wall, Ivan

PY - 2015/1/8

Y1 - 2015/1/8

N2 - Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21st century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

AB - Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21st century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

UR - https://www.scopus.com/pages/publications/84920712394

U2 - 10.1016/j.stem.2014.12.013

DO - 10.1016/j.stem.2014.12.013

M3 - Review Article

C2 - 25575079

AN - SCOPUS:84920712394

SN - 1934-5909

VL - 16

SP - 13

EP - 17

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 1

ER -

Generating iPSCs: Translating cell reprogramming science into scalable and robust biomanufacturing strategies

Abstract

Access to Document

Other files and links

Cite this