Generating iPSCs: Translating cell reprogramming science into scalable and robust biomanufacturing strategies

Marli Silva, Laurence Daheron, Hannah Hurley, Kim Bure, Richard Barker, Andrew J. Carr, David Williams, Hae Won Kim, Anna French, Pete J. Coffey, Justin J. Cooper-White, Brock Reeve, Mahendra S Rao, Evan Y. Snyder, Kelvin S. Ng, Benjamin E. Mead, James A. Smith, Jeffrey M. Karp, David A. Brindley, Ivan Wall

Research output: Contribution to journalReview ArticleOtherpeer-review

43 Citations (Scopus)

Abstract

Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21st century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalCell Stem Cell
Volume16
Issue number1
DOIs
Publication statusPublished - 8 Jan 2015
Externally publishedYes

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