General nature of the STAT3-activated anti-inflammatory response

Karim C. El Kasmi, Jeff Holst, Maryaline Coffre, Lisa Mielke, Antoine De Pauw, Nouara Lhocine, Amber M. Smith, Robert Rutschman, Deepak Kaushal, Yuhong Shen, Takashi Suda, Raymond P. Donnelly, Martin G. Myers, Warren Alexander, Dario A.A. Vignali, Stephanie S. Watowich, Matthias Ernst, Douglas J. Hilton, Peter J. Murray

Research output: Contribution to journalArticleResearchpeer-review

182 Citations (Scopus)


Although many cytokine receptors generate their signals via the STAT3 pathway, the IL-10R appears unique in promoting a potent anti-inflammatory response (AIR) via STAT3 to antagonize proinflammatory signals that activate the innate immune response. We found that heterologous cytokine receptor systems that activate STAT3 but are naturally refractory (the IL-22R), or engineered to be refractory (the IL-6, leptin, and erythropoietin receptors), to suppressor of cytokine signaling-3-mediated inhibition activate an AIR indistinguishable from IL-10. We conclude that the AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R.

Original languageEnglish
Pages (from-to)7880-7888
Number of pages9
JournalJournal of Immunology
Issue number11
Publication statusPublished - 1 Dec 2006
Externally publishedYes

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