General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance

Alex Fornito, Jong H Yoon, Andrew Zalesky, Edward Bullmore, Cameron Sue Carter

Research output: Contribution to journalArticleResearchpeer-review

234 Citations (Scopus)

Abstract

Background Cognitive control impairments in schizophrenia are thought to arise from dysfunction of interconnected networks of brain regions, but interrogating the functional dynamics of large-scale brain networks during cognitive task performance has proved difficult. We used functional magnetic resonance imaging to generate event-related whole-brain functional connectivity networks in participants with first-episode schizophrenia and healthy control subjects performing a cognitive control task.
Original languageEnglish
Pages (from-to)64-72
Number of pages9
JournalBiological Psychiatry
Volume70
Issue number1
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Keywords

  • complex
  • executive function
  • fMRI
  • graph
  • psychosis
  • small world

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