Gene expression and the development of live enteric vaccines

Ian Charles, Gordon Dougan

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Rationally attenuated live Salmonella vaccines provide good protection against homologous challenge and can act as carriers of heterologous antigens. However, the optimum expression system for each heterologous antigen will need to be established individually. This will ensure that the antigen in question is produced at appropriate levels, in the correctly folded conformation, within or at the surface of the carrier cell, and can therefore elicit the optimal immune response.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalTrends in Biotechnology
Volume8
Issue numberC
DOIs
Publication statusPublished - 1 Jan 1990
Externally publishedYes

Cite this

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Gene expression and the development of live enteric vaccines. / Charles, Ian; Dougan, Gordon.

In: Trends in Biotechnology, Vol. 8, No. C, 01.01.1990, p. 117-121.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Dougan, Gordon

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AB - Rationally attenuated live Salmonella vaccines provide good protection against homologous challenge and can act as carriers of heterologous antigens. However, the optimum expression system for each heterologous antigen will need to be established individually. This will ensure that the antigen in question is produced at appropriate levels, in the correctly folded conformation, within or at the surface of the carrier cell, and can therefore elicit the optimal immune response.

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