Gene-engineered T cells for cancer therapy

Michael H Kershaw, Jennifer A Westwood, Phillip K Darcy

Research output: Contribution to journalArticleResearchpeer-review

314 Citations (Scopus)


T cells have the capacity to eradicate diseased cells, but tumours present considerable challenges that render T cells ineffectual. Cancer cells often make themselves almost invisible to the immune system, and they sculpt a microenvironment that suppresses T cell activity, survival and migration. Genetic engineering of T cells can be used therapeutically to overcome these challenges. T cells can be taken from the blood of cancer patients and then modified with genes encoding receptors that recognize cancer-specific antigens. Additional genes can be used to enable resistance to immunosuppression, to extend survival and to facilitate the penetration of engineered T cells into tumours. Using genetic modification, highly active, self-propagating slayers of cancer cells can be generated. ? 2013 Macmillan Publishers Limited
Original languageEnglish
Pages (from-to)525 - 541
Number of pages17
JournalNature Reviews Cancer
Issue number8
Publication statusPublished - 2013

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