Gender differences in pressure-natriuresis and renal autoregulation: Role of the Angiotensin type 2 receptor

Lucinda M Hilliard, Mehdi Nematbakhsh, Michelle M Kett, Elleesha Teichman, Amanda K Sampson, Robert E Widdop, Roger G Evans, Katherine M Denton

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Abstract

Sexual dimorphism in arterial pressure regulation has been observed in humans and animal models. The mechanisms underlying this gender difference are not fully known. Previous studies in rats have shown that females excrete more salt than males at a similar arterial pressure. The renin-angiotensin system is a powerful regulator of arterial pressure and body fluid volume. This study examined the role of the angiotensin type 2 receptor (AT(2)R) in pressure-natriuresis in male and female rats because AT(2)R expression has been reported to be enhanced in females. Renal function was examined at renal perfusion pressures of 120, 100, and 80 mm Hg in vehicle-treated and AT(2)R antagonist-treated (PD123319; 1 mg/kg/h) groups. The pressure-natriuresis relationship was gender-dependent such that it was shifted upward in female vs male rats (P
Original languageEnglish
Pages (from-to)275 - 282
Number of pages8
JournalHypertension
Volume57
Issue number2
DOIs
Publication statusPublished - 2011

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