@article{7d997c86a1194f808e620e01d85a4705,
title = "Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study",
abstract = "Purpose: To assess the impact of gender and pre-menopausal state on short- and long-term outcomes in patients with septic shock. Material and methods: Cohort study of the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial, an international randomized controlled trial comparing early goal-directed therapy (EGDT) to usual care in patients with early septic shock, conducted between October 2008 and April 2014. The primary exposure in this analysis was legal gender and the secondary exposure was pre-menopausal state defined by chronological age (≤ 50 years). Results: 641 (40.3%) of all 1591 ARISE trial participants in the intention-to-treat population were females and overall, 337 (21.2%) (146 females) patients were 50 years of age or younger. After risk-adjustment, we could not identify any survival benefit for female patients at day 90 in the younger (≤50 years) (adjusted Odds Ratio (aOR): 0.91 (0.46–1.89), p =.85) nor in the older (>50 years) age-group (aOR: 1.10 (0.81–1.49), p =.56). Similarly, there was no gender-difference in ICU, hospital, 1-year mortality nor quality of life measures. Conclusions: This post-hoc analysis of a large multi-center trial in early septic shock has shown no short- or long-term survival effect for women overall as well as in the pre-menopausal age-group.",
keywords = "Age, Gender difference, Intensive care, Outcomes, Pre-menopausal state, Sepsis, Septic shock, Sex",
author = "Nora Luethi and Michael Bailey and Alisa Higgins and Belinda Howe and Sandra Peake and Anthony Delaney and Rinaldo Bellomo and {the ARISE investigators} and P. Cameron and A. Holdgate and Webb, {S. A. R.} and P. Williams and Cooper, {D. J.} and A. Cross and Gomersall, {C. D.} and C. Graham and I. Jacobs and S. Johanson and P. Jones and P. Kruger and C. McArthur and J. Myburgh and A. Nichol and V. Pettila and D. Rajbhandari and A. Williams and J. Williams and V. Bennett and J. Board and P. McCracken and S. McGloughlin and V. Nanjayya and A. Teo and E. Hill and E. O'Brien and F. Sawtell and K. Schimanski and D. Wilson and Simon Bolch and G. Eastwood and F. Kerr and L. Peak and H. Young and J. Edington and J. Fletcher and J. Smith and D. Ghelani and K. Nand and T. Sara and D. Flemming and M. Grummisch and A. Purdue and E. Fulton and K. Grove and A. Harney and K. Milburn and R. Millar and I. Mitchell and Helen Rodgers and Sinead Scanlon and T. Coles and H. Connor and J. Dennett and {Van Berkel}, A. and S. Barrington-Onslow and S. Henderson and J. Mehrtens and J. Dryburgh and A. Tankel and G. Braitberg and B. O'Bree and K. Shepherd and S. Vij and S. Allsop and D. Haji and K. Haji and J. Vuat and A. Bone and T. Elderkin and N. Orford and M. Ragg and S. Kelly and D. Stewart and N. Woodward and V.-P. Harjola and M. Okkonen and S. Sutinen and E. Wilkman and J. Fratzia and J. Halkhoree and S. Treloar and K. Ryan and T. Sandford and J. Walsham and C. Jenkins and D. Williamson and J. Burrows and D. Hawkins and C. Tang and A. Dimakis and S. Micallef and M. Parr and H. White and L. Morrison and K. Sosnowski and R. Ramadoss and N. Soar and J. Wood and M. Franks and C. Hogan and R. Song and A. Tilsley and D. Rainsford and R. Wells and J. Dowling and P. Galt and T. Lamac and D. Lightfoot and C. Walker and K. Braid and T. DeVillecourt and Tan, {H. S.} and Ian Seppelt and Chang, {L. F.} and Cheung, {W. S.} and Fok, {S. K.} and K. Lam and Lam, {S. M.} and So, {H. M.} and Yan, {W. W.} and A. Altea and B. Lancashire and P. Leung and S. Arora and F. Bass and Y. Shehabi and J. Isoardi and K. Isoardi and D. Powrie and S. Lawrence and A. Ankor and L. Chester and M. Davies and S. O'Connor and A. Poole and T. Soulsby and K. Sundararajan and Greenslade, {J. H.} and C. Macisaac and K. Gorman and A. Jordan and L. Moore and S. Ankers and S. Bird and T. Fogg and E. Hickson and T. Jewell and K. Kyneur and A. O'Connor and J. Townsend and E. Yarad and S. Brown and J. Chamberlain and J. Cooper and E. Jenkinson and E. McDonald and Heidi Buhr and J. Coakley and J. Cowell and D. Hutch and D. Gattas and M. Keir and C. Rees and S. Baker and B. Roberts and E. Farone and J. Holmes and J. Santamaria and C. Winter and A. Finckh and S. Knowles and J. McCabe and P. Nair and C. Reynolds and B. Ahmed and D. Barton and E. Meaney and R. Harris and L. Shields and K. Thomas and S. Karlsson and A. Kuitunen and A. Kukkurainen and J. Tenhunen and S. Varila and N. Ryan and C. Trethewy and J. Crosdale and Smith, {J. C.} and M. Vellaichamy and J. Furyk and G. Gordon and L. Jones and S. Senthuran and S. Bates and J. Butler and C. French and A. Tippett and J. Kelly and J. Kwans and M. Murphy and D. O'Flynn and C. Kurenda and T. Otto and V. Raniga and Ho, {H. F.} and A. Leung and H. Wu",
year = "2020",
month = feb,
doi = "10.1016/j.jcrc.2019.11.002",
language = "English",
volume = "55",
pages = "177--183",
journal = "Journal of Critical Care",
issn = "0883-9441",
publisher = "Elsevier",
}