Gender differences in health-related quality of life following ST-elevation myocardial infarction: women and men do not benefit from primary percutaneous coronary intervention to the same degree

Ole Steen Mortensen, Jacob Bjorner, Beth Newman, Brian Federick Oldenburg, Mogens Groenvold, Jan K Madsen, Henning Andersen, on behalf of the DANAMI-2 Study Group

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BACKGROUND: There is limited evidence whether women benefit to the same degree as men from treatment of myocardial infarction with percutaneous coronary intervention (PCI) when compared to fibrinolysis. This study compares health-related quality of life (HRQoL) outcomes for men and women randomized to primary PCI and fibrinolysis. DESIGN: A questionnaire-based study in 1351 patients with ST-elevation myocardial infarction (STEMI), assessed at 1 and 12 months after the infarction. METHODS: HRQoL was measured with the Medical Outcomes Study Short Form (SF-36), the Hospital Anxiety and Depression Scale (HADS), Rose s angina and dyspnoea questionnaire and global QoL questions. RESULTS: Women had a worse score than men on all endpoints at 1 month and at several endpoints at 12 months. In analyses of gender differences in benefits of PCI 1 month after the STEMI, significant gender differences were found in the SF-36 mental component summary scale, with men having better scores after primary PCI and women having better scores after fibrinolysis (P=0.03). At 12 months, similar gender differences in treatment benefit were found in the SF-36 scales for general health (P=0.01), mental health (P
Original languageEnglish
Pages (from-to)37 - 43
Number of pages7
JournalEuropean Journal of Cardiovascular Prevention & Rehabilitation
Issue number1
Publication statusPublished - 2007

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