Gelsolin suppresses gastric cancer metastasis through inhibition of PKR-p38 signaling

Xiangliang Yuan; Weiwei Wang; Junhua Li; Peiming Zheng; Ping Dong; Lei Chen; Yunlan Zhou; Guohua Xie; Dakang Xu; Yingbin Liu; Lisong Shen

doi:10.18632/oncotarget.10557

Gelsolin suppresses gastric cancer metastasis through inhibition of PKR-p38 signaling

Xiangliang Yuan, Weiwei Wang, Junhua Li, Peiming Zheng, Ping Dong, Lei Chen, Yunlan Zhou, Guohua Xie, Dakang Xu, Yingbin Liu, Lisong Shen

Hudson Institute - Department of Molecular and Translational Science

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

The biological function of gelsolin in gastric cancer and its mechanism remained undefined. Here, we demonstrated that gelsolin was down-regulated in human gastric cancer tissues, and lower tumorous gelsolin significantly correlated with gastric cancer metastasis. Functionally, gelsolin suppressed the migration of gastric cancer cells in vitro and inhibited lung metastasis in vivo. In mechanism, gelsolin decreased epithelial-mesenchymal transition (EMT) inducing cytoskeleton remolding through inhibition of p38 signaling to suppress the migration of gastric cancer cell. Moreover, gelsolin bound to and decreased the phosphorylation of PKR, and then inhibited p38 signaling pathway. Finally, similar to the gastric cancer cell lines, PKR-p38 signaling pathway proteins tend to be activated and correlated with low expression of gelsolin in clinical gastric cancer tissues. Altogether, these results highlight the importance of gelsolin in suppression of gastric cancer metastasis through inhibition of PKR-p38 signaling pathway.

Original language	English
Pages (from-to)	53459-53470
Number of pages	12
Journal	Oncotarget
Volume	7
Issue number	33
DOIs	https://doi.org/10.18632/oncotarget.10557
Publication status	Published - 13 Jul 2016

Keywords

Gastric cancer
Gelsolin
Metastasis
p38MAPK protein kinase
PKR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.10557

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title = "Gelsolin suppresses gastric cancer metastasis through inhibition of PKR-p38 signaling",

abstract = "The biological function of gelsolin in gastric cancer and its mechanism remained undefined. Here, we demonstrated that gelsolin was down-regulated in human gastric cancer tissues, and lower tumorous gelsolin significantly correlated with gastric cancer metastasis. Functionally, gelsolin suppressed the migration of gastric cancer cells in vitro and inhibited lung metastasis in vivo. In mechanism, gelsolin decreased epithelial-mesenchymal transition (EMT) inducing cytoskeleton remolding through inhibition of p38 signaling to suppress the migration of gastric cancer cell. Moreover, gelsolin bound to and decreased the phosphorylation of PKR, and then inhibited p38 signaling pathway. Finally, similar to the gastric cancer cell lines, PKR-p38 signaling pathway proteins tend to be activated and correlated with low expression of gelsolin in clinical gastric cancer tissues. Altogether, these results highlight the importance of gelsolin in suppression of gastric cancer metastasis through inhibition of PKR-p38 signaling pathway.",

keywords = "Gastric cancer, Gelsolin, Metastasis, p38MAPK protein kinase, PKR",

author = "Xiangliang Yuan and Weiwei Wang and Junhua Li and Peiming Zheng and Ping Dong and Lei Chen and Yunlan Zhou and Guohua Xie and Dakang Xu and Yingbin Liu and Lisong Shen",

year = "2016",

month = jul,

day = "13",

doi = "10.18632/oncotarget.10557",

language = "English",

volume = "7",

pages = "53459--53470",

journal = "Oncotarget",

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T1 - Gelsolin suppresses gastric cancer metastasis through inhibition of PKR-p38 signaling

AU - Yuan, Xiangliang

AU - Wang, Weiwei

AU - Li, Junhua

AU - Zheng, Peiming

AU - Dong, Ping

AU - Chen, Lei

AU - Zhou, Yunlan

AU - Xie, Guohua

AU - Xu, Dakang

AU - Liu, Yingbin

AU - Shen, Lisong

PY - 2016/7/13

Y1 - 2016/7/13

N2 - The biological function of gelsolin in gastric cancer and its mechanism remained undefined. Here, we demonstrated that gelsolin was down-regulated in human gastric cancer tissues, and lower tumorous gelsolin significantly correlated with gastric cancer metastasis. Functionally, gelsolin suppressed the migration of gastric cancer cells in vitro and inhibited lung metastasis in vivo. In mechanism, gelsolin decreased epithelial-mesenchymal transition (EMT) inducing cytoskeleton remolding through inhibition of p38 signaling to suppress the migration of gastric cancer cell. Moreover, gelsolin bound to and decreased the phosphorylation of PKR, and then inhibited p38 signaling pathway. Finally, similar to the gastric cancer cell lines, PKR-p38 signaling pathway proteins tend to be activated and correlated with low expression of gelsolin in clinical gastric cancer tissues. Altogether, these results highlight the importance of gelsolin in suppression of gastric cancer metastasis through inhibition of PKR-p38 signaling pathway.

AB - The biological function of gelsolin in gastric cancer and its mechanism remained undefined. Here, we demonstrated that gelsolin was down-regulated in human gastric cancer tissues, and lower tumorous gelsolin significantly correlated with gastric cancer metastasis. Functionally, gelsolin suppressed the migration of gastric cancer cells in vitro and inhibited lung metastasis in vivo. In mechanism, gelsolin decreased epithelial-mesenchymal transition (EMT) inducing cytoskeleton remolding through inhibition of p38 signaling to suppress the migration of gastric cancer cell. Moreover, gelsolin bound to and decreased the phosphorylation of PKR, and then inhibited p38 signaling pathway. Finally, similar to the gastric cancer cell lines, PKR-p38 signaling pathway proteins tend to be activated and correlated with low expression of gelsolin in clinical gastric cancer tissues. Altogether, these results highlight the importance of gelsolin in suppression of gastric cancer metastasis through inhibition of PKR-p38 signaling pathway.

KW - Gastric cancer

KW - Gelsolin

KW - Metastasis

KW - p38MAPK protein kinase

KW - PKR

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U2 - 10.18632/oncotarget.10557

DO - 10.18632/oncotarget.10557

M3 - Article

AN - SCOPUS:84982275944

SN - 1949-2553

VL - 7

SP - 53459

EP - 53470

JO - Oncotarget

JF - Oncotarget

IS - 33

ER -

Gelsolin suppresses gastric cancer metastasis through inhibition of PKR-p38 signaling

Abstract

Keywords

UN SDGs

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