Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders

Lv Wang, Michael Allan Conlon, Claus Thagaard Christophersen, Michael Joseph Sorich, Manya Therese Angley

Research output: Contribution to journalReview ArticleResearchpeer-review

37 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Many affected individuals also display symptoms of gastrointestinal (GI) disturbance, suggesting GI factors may play an important role in the pathogenesis of ASD and/or related complications. The current review will focus on evidence supporting a role for the GI microbiota and their fermentation products in the etiology and/or symptoms of ASD, and their potential use as biomarkers. GI-related biomarkers could potentially enable early identification of ASD at risk of GI disturbance, and thereby guide targeted interventions, potentially improving the health and quality of life of affected individuals.

Original languageEnglish
Pages (from-to)331-344
Number of pages14
JournalBiomarkers in Medicine
Volume8
Issue number3
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • autism spectrum disorder
  • gastrointestinal
  • metabolite biomarkers
  • microbiota

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