Gastrin is not required for liver regeneration

Amra Dizdarevic, Nadia Harun, Cathy Malcontenti-Wilson, Arthur Shulkes, Christopher Christophi, Grham S Baldwin

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND: Although several growth factors are known to be essential for liver regeneration, the role of gastrin remains controversial. METHODS: Liver regeneration was examined in wild-type (WT) and gastrin-deficient (gastrin KO) mice at days 2 and 10 after partial (40 ) hepatectomy by measurement of liver weight. Hepatocyte proliferation and circulating gastrin concentrations were measured at the same time points by immunohistochemistry and radioimmunoassay, respectively. RESULTS: There was no significant difference in the rate of liver regeneration between gastrin KO and WT mice. Hepatocyte proliferation in both groups was increased at day 2 but had returned to baseline values by day 10. At day 2, hepatocyte proliferation in the gastrin KO mice was significantly higher than in WT animals, whereas at day 10, proliferation was significantly greater in the WT mice. The circulating gastrin concentration in the WT mice was significantly lower at day 10 than in unoperated WT animals. CONCLUSION: This study suggests that gastrin is not essential for liver regeneration after partial hepatectomy.
Original languageEnglish
Pages (from-to)68 - 71
Number of pages4
JournalANZ Journal of Surgery
Volume78
Issue number1-2
DOIs
Publication statusPublished - 2008
Externally publishedYes

Cite this

Dizdarevic, A., Harun, N., Malcontenti-Wilson, C., Shulkes, A., Christophi, C., & Baldwin, G. S. (2008). Gastrin is not required for liver regeneration. ANZ Journal of Surgery, 78(1-2), 68 - 71. https://doi.org/10.1111/j.1445-2197.2007.04360.x
Dizdarevic, Amra ; Harun, Nadia ; Malcontenti-Wilson, Cathy ; Shulkes, Arthur ; Christophi, Christopher ; Baldwin, Grham S. / Gastrin is not required for liver regeneration. In: ANZ Journal of Surgery. 2008 ; Vol. 78, No. 1-2. pp. 68 - 71.
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abstract = "BACKGROUND: Although several growth factors are known to be essential for liver regeneration, the role of gastrin remains controversial. METHODS: Liver regeneration was examined in wild-type (WT) and gastrin-deficient (gastrin KO) mice at days 2 and 10 after partial (40 ) hepatectomy by measurement of liver weight. Hepatocyte proliferation and circulating gastrin concentrations were measured at the same time points by immunohistochemistry and radioimmunoassay, respectively. RESULTS: There was no significant difference in the rate of liver regeneration between gastrin KO and WT mice. Hepatocyte proliferation in both groups was increased at day 2 but had returned to baseline values by day 10. At day 2, hepatocyte proliferation in the gastrin KO mice was significantly higher than in WT animals, whereas at day 10, proliferation was significantly greater in the WT mice. The circulating gastrin concentration in the WT mice was significantly lower at day 10 than in unoperated WT animals. CONCLUSION: This study suggests that gastrin is not essential for liver regeneration after partial hepatectomy.",
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Dizdarevic, A, Harun, N, Malcontenti-Wilson, C, Shulkes, A, Christophi, C & Baldwin, GS 2008, 'Gastrin is not required for liver regeneration', ANZ Journal of Surgery, vol. 78, no. 1-2, pp. 68 - 71. https://doi.org/10.1111/j.1445-2197.2007.04360.x

Gastrin is not required for liver regeneration. / Dizdarevic, Amra; Harun, Nadia; Malcontenti-Wilson, Cathy; Shulkes, Arthur; Christophi, Christopher; Baldwin, Grham S.

In: ANZ Journal of Surgery, Vol. 78, No. 1-2, 2008, p. 68 - 71.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Dizdarevic, Amra

AU - Harun, Nadia

AU - Malcontenti-Wilson, Cathy

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AU - Christophi, Christopher

AU - Baldwin, Grham S

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AB - BACKGROUND: Although several growth factors are known to be essential for liver regeneration, the role of gastrin remains controversial. METHODS: Liver regeneration was examined in wild-type (WT) and gastrin-deficient (gastrin KO) mice at days 2 and 10 after partial (40 ) hepatectomy by measurement of liver weight. Hepatocyte proliferation and circulating gastrin concentrations were measured at the same time points by immunohistochemistry and radioimmunoassay, respectively. RESULTS: There was no significant difference in the rate of liver regeneration between gastrin KO and WT mice. Hepatocyte proliferation in both groups was increased at day 2 but had returned to baseline values by day 10. At day 2, hepatocyte proliferation in the gastrin KO mice was significantly higher than in WT animals, whereas at day 10, proliferation was significantly greater in the WT mice. The circulating gastrin concentration in the WT mice was significantly lower at day 10 than in unoperated WT animals. CONCLUSION: This study suggests that gastrin is not essential for liver regeneration after partial hepatectomy.

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Dizdarevic A, Harun N, Malcontenti-Wilson C, Shulkes A, Christophi C, Baldwin GS. Gastrin is not required for liver regeneration. ANZ Journal of Surgery. 2008;78(1-2):68 - 71. https://doi.org/10.1111/j.1445-2197.2007.04360.x