Gas-Generating, pH-Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast-Enhanced Ultrasound Imaging

Mark Louis P. Vidallon, Alon M. Douek, Adam Quek, Heather McLiesh, Jan Kaslin, Rico F. Tabor, Alexis I. Bishop, Boon Mian Teo

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)


This work reports the fabrication of biocompatible and pH-sensitive hybrid polydopamine/bovine serum albumin/calcium carbonate (PDA/BSA/CaCO3) particles via a rapid precipitation method. These hybrid particles generate hyperechogenic carbon dioxide bubbles upon exposure to low pH environments, making them ideal as a contrast agent and detector for tumor cells. This study also highlights the application of red blood cell membrane (RBC)-derived membranes as a biomimetic coating for PDA/BSA/CaCO3 hybrid particles in order to modulate protein corona formation, a natural physiological response that alters tailored properties of most nanomaterials that are administered systemically. Results of this work demonstrate that the RBC membrane-coated hybrid particles are ideal for a wide range of biomedical applications, such as noninvasive multimodal imaging, photothermal and photodynamic therapy, and “personalized” drug delivery systems.

Original languageEnglish
Article number1900471
Number of pages8
JournalParticle and Particle Systems Characterization
Issue number2
Publication statusPublished - Feb 2020


  • calcium carbonate nanoparticles
  • contrast enhanced ultrasound imaging
  • protein corona
  • red blood cell membranes

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