Abstract
This work reports the fabrication of biocompatible and pH-sensitive hybrid polydopamine/bovine serum albumin/calcium carbonate (PDA/BSA/CaCO3) particles via a rapid precipitation method. These hybrid particles generate hyperechogenic carbon dioxide bubbles upon exposure to low pH environments, making them ideal as a contrast agent and detector for tumor cells. This study also highlights the application of red blood cell membrane (RBC)-derived membranes as a biomimetic coating for PDA/BSA/CaCO3 hybrid particles in order to modulate protein corona formation, a natural physiological response that alters tailored properties of most nanomaterials that are administered systemically. Results of this work demonstrate that the RBC membrane-coated hybrid particles are ideal for a wide range of biomedical applications, such as noninvasive multimodal imaging, photothermal and photodynamic therapy, and “personalized” drug delivery systems.
Original language | English |
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Article number | 1900471 |
Number of pages | 8 |
Journal | Particle and Particle Systems Characterization |
Volume | 37 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2020 |
Keywords
- calcium carbonate nanoparticles
- contrast enhanced ultrasound imaging
- protein corona
- red blood cell membranes
Equipment
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Centre for Electron Microscopy (MCEM)
Peter Miller (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility