GAS CHROMATOGRAPHIC MEASUREMENT OF PLASMA LEVELS OF SODIUM VALPROATE: TENTATIVE THERAPEUTIC RANGE OF A NEW ANTICONVULSANT IN THE TREATMENT OF REFRACTORY EPILEPTICS

F. J.E. Vajda; O. H. Drummer; P. M. Morris; J. J. McNeil; P. F. Bladin

doi:10.1111/j.1440-1681.1978.tb00653.x

GAS CHROMATOGRAPHIC MEASUREMENT OF PLASMA LEVELS OF SODIUM VALPROATE: TENTATIVE THERAPEUTIC RANGE OF A NEW ANTICONVULSANT IN THE TREATMENT OF REFRACTORY EPILEPTICS

F. J.E. Vajda, O. H. Drummer, P. M. Morris, J. J. McNeil, P. F. Bladin

Research output: Contribution to journal › Article › Research › peer-review

37 Citations (Scopus)

Abstract

1. A precise and rapid gas chromatographic method for the measurement of plasma sodium valproate concentrations is presented. 2. The extraction is a single step procedure, and is reproducible and linear throughout the concentration range encountered. 3. Clinical evaluation of the drug is presented in eighteen epileptics on the basis of the percentage of days on which subjects had seizures before and after sodium valproate therapy. 4. A tentative therapeutic range for sodium valproate is presented on the basis of plasma levels and therapeutic effect.

Original language	English
Pages (from-to)	67-73
Number of pages	7
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1111/j.1440-1681.1978.tb00653.x
Publication status	Published - 1 Jan 1978
Externally published	Yes

Keywords

GLC
plasma
refractory epileptics
sodium valproate
therapeutic range

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10.1111/j.1440-1681.1978.tb00653.x

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Vajda, F. J. E., Drummer, O. H., Morris, P. M., McNeil, J. J., & Bladin, P. F. (1978). GAS CHROMATOGRAPHIC MEASUREMENT OF PLASMA LEVELS OF SODIUM VALPROATE: TENTATIVE THERAPEUTIC RANGE OF A NEW ANTICONVULSANT IN THE TREATMENT OF REFRACTORY EPILEPTICS. Clinical and Experimental Pharmacology and Physiology, 5(1), 67-73. https://doi.org/10.1111/j.1440-1681.1978.tb00653.x

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title = "GAS CHROMATOGRAPHIC MEASUREMENT OF PLASMA LEVELS OF SODIUM VALPROATE: TENTATIVE THERAPEUTIC RANGE OF A NEW ANTICONVULSANT IN THE TREATMENT OF REFRACTORY EPILEPTICS",

abstract = "1. A precise and rapid gas chromatographic method for the measurement of plasma sodium valproate concentrations is presented. 2. The extraction is a single step procedure, and is reproducible and linear throughout the concentration range encountered. 3. Clinical evaluation of the drug is presented in eighteen epileptics on the basis of the percentage of days on which subjects had seizures before and after sodium valproate therapy. 4. A tentative therapeutic range for sodium valproate is presented on the basis of plasma levels and therapeutic effect.",

keywords = "GLC, plasma, refractory epileptics, sodium valproate, therapeutic range",

author = "Vajda, {F. J.E.} and Drummer, {O. H.} and Morris, {P. M.} and McNeil, {J. J.} and Bladin, {P. F.}",

year = "1978",

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doi = "10.1111/j.1440-1681.1978.tb00653.x",

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pages = "67--73",

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}

GAS CHROMATOGRAPHIC MEASUREMENT OF PLASMA LEVELS OF SODIUM VALPROATE: TENTATIVE THERAPEUTIC RANGE OF A NEW ANTICONVULSANT IN THE TREATMENT OF REFRACTORY EPILEPTICS. / Vajda, F. J.E.; Drummer, O. H.; Morris, P. M. et al.
In: Clinical and Experimental Pharmacology and Physiology, Vol. 5, No. 1, 01.01.1978, p. 67-73.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - GAS CHROMATOGRAPHIC MEASUREMENT OF PLASMA LEVELS OF SODIUM VALPROATE

T2 - TENTATIVE THERAPEUTIC RANGE OF A NEW ANTICONVULSANT IN THE TREATMENT OF REFRACTORY EPILEPTICS

AU - Vajda, F. J.E.

AU - Drummer, O. H.

AU - Morris, P. M.

AU - McNeil, J. J.

AU - Bladin, P. F.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - 1. A precise and rapid gas chromatographic method for the measurement of plasma sodium valproate concentrations is presented. 2. The extraction is a single step procedure, and is reproducible and linear throughout the concentration range encountered. 3. Clinical evaluation of the drug is presented in eighteen epileptics on the basis of the percentage of days on which subjects had seizures before and after sodium valproate therapy. 4. A tentative therapeutic range for sodium valproate is presented on the basis of plasma levels and therapeutic effect.

AB - 1. A precise and rapid gas chromatographic method for the measurement of plasma sodium valproate concentrations is presented. 2. The extraction is a single step procedure, and is reproducible and linear throughout the concentration range encountered. 3. Clinical evaluation of the drug is presented in eighteen epileptics on the basis of the percentage of days on which subjects had seizures before and after sodium valproate therapy. 4. A tentative therapeutic range for sodium valproate is presented on the basis of plasma levels and therapeutic effect.

KW - GLC

KW - plasma

KW - refractory epileptics

KW - sodium valproate

KW - therapeutic range

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U2 - 10.1111/j.1440-1681.1978.tb00653.x

DO - 10.1111/j.1440-1681.1978.tb00653.x

M3 - Article

C2 - 346272

AN - SCOPUS:0018143774

SN - 0305-1870

VL - 5

SP - 67

EP - 73

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

IS - 1

ER -

GAS CHROMATOGRAPHIC MEASUREMENT OF PLASMA LEVELS OF SODIUM VALPROATE: TENTATIVE THERAPEUTIC RANGE OF A NEW ANTICONVULSANT IN THE TREATMENT OF REFRACTORY EPILEPTICS

Abstract

Keywords

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