Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Garlic-derived polysulfides (e.g., diallyl trisulfide, DATS) act as potent donors of the cell-signalling mediator H2S when exposed to endogenous thiols. Inspired by this chemistry, we incorporated a trisulfide linkage into a conjugate comprising an mPEG tail and a cholesteryl head via thiol-mediated fragmentation chemistry. The synthesized conjugate releases H2S upon exposure to thiol even at intracellular levels.

Original languageEnglish
Pages (from-to)8030-8033
Number of pages4
JournalChemical Communications
Volume53
Issue number57
DOIs
Publication statusPublished - 2017

Cite this

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title = "Garlic-inspired trisulfide linkers for thiol-stimulated H2S release",
abstract = "Garlic-derived polysulfides (e.g., diallyl trisulfide, DATS) act as potent donors of the cell-signalling mediator H2S when exposed to endogenous thiols. Inspired by this chemistry, we incorporated a trisulfide linkage into a conjugate comprising an mPEG tail and a cholesteryl head via thiol-mediated fragmentation chemistry. The synthesized conjugate releases H2S upon exposure to thiol even at intracellular levels.",
author = "Francesca Ercole and Whittaker, {Michael R} and Halls, {Michelle L} and Boyd, {Ben J} and Davis, {Thomas P} and Quinn, {John F}",
year = "2017",
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volume = "53",
pages = "8030--8033",
journal = "Chemical Communications",
issn = "1359-7345",
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Garlic-inspired trisulfide linkers for thiol-stimulated H2S release. / Ercole, Francesca; Whittaker, Michael R; Halls, Michelle L; Boyd, Ben J; Davis, Thomas P; Quinn, John F.

In: Chemical Communications, Vol. 53, No. 57, 2017, p. 8030-8033.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

AU - Ercole, Francesca

AU - Whittaker, Michael R

AU - Halls, Michelle L

AU - Boyd, Ben J

AU - Davis, Thomas P

AU - Quinn, John F

PY - 2017

Y1 - 2017

N2 - Garlic-derived polysulfides (e.g., diallyl trisulfide, DATS) act as potent donors of the cell-signalling mediator H2S when exposed to endogenous thiols. Inspired by this chemistry, we incorporated a trisulfide linkage into a conjugate comprising an mPEG tail and a cholesteryl head via thiol-mediated fragmentation chemistry. The synthesized conjugate releases H2S upon exposure to thiol even at intracellular levels.

AB - Garlic-derived polysulfides (e.g., diallyl trisulfide, DATS) act as potent donors of the cell-signalling mediator H2S when exposed to endogenous thiols. Inspired by this chemistry, we incorporated a trisulfide linkage into a conjugate comprising an mPEG tail and a cholesteryl head via thiol-mediated fragmentation chemistry. The synthesized conjugate releases H2S upon exposure to thiol even at intracellular levels.

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U2 - 10.1039/c7cc03820h

DO - 10.1039/c7cc03820h

M3 - Article

VL - 53

SP - 8030

EP - 8033

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 57

ER -