Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

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Abstract

Garlic-derived polysulfides (e.g., diallyl trisulfide, DATS) act as potent donors of the cell-signalling mediator H2S when exposed to endogenous thiols. Inspired by this chemistry, we incorporated a trisulfide linkage into a conjugate comprising an mPEG tail and a cholesteryl head via thiol-mediated fragmentation chemistry. The synthesized conjugate releases H2S upon exposure to thiol even at intracellular levels.

Original languageEnglish
Pages (from-to)8030-8033
Number of pages4
JournalChemical Communications
Volume53
Issue number57
DOIs
Publication statusPublished - 2017

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