TY - JOUR
T1 - Ganoderma lucidum and auricularia polytricha mushrooms protect against carbofuran-iInduced toxicity in rats
AU - Hossen, Md Sakib
AU - Billah Prince, Md Maruf
AU - Tanvir, E. M.
AU - Chowdhury, M. Alamgir Zaman
AU - Rahman, Md Abdur
AU - Alam, Fahmida
AU - Paul, Sudip
AU - Saha, Moumoni
AU - Ali, Md Yousuf
AU - Bhoumik, Nikhil Chandra
AU - Karim, Nurul
AU - Gan, Siew Hua
AU - Khalil, Md Ibrahim
N1 - Funding Information:
This research was partly supported by the University Grants Commission of Bangladesh, 2015, and the National Science and Technology (NST) special allocation 2013-1014, no. 8 (BS 130). The authors would like to acknowledge Mushroom Development and Extension Centre, Savar, Bangladesh, and the Universiti Sains Malaysia (USM) Global Fellowship (2014/2015) awarded to Fahmida Alam during her Ph.D. degree.
Publisher Copyright:
© 2018 Md. Sakib Hossen et al.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/5/15
Y1 - 2018/5/15
N2 - The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran- (CF) induced toxicity in rats. Male Wistar rats (n=42) were divided into six equal groups. The rats in the negative control group received oral administration of CF at 1 mg/kg with the normal diet for 28 days. The treatment groups received oral administration of ethanolic extract of GL or AP at 100 mg/kg followed by coadministration of CF at 1 mg/kg with the normal diet for the same experimental period, respectively. In the CF alone treated group, there were significant decreases in the erythrocytic and thrombocytic indices but increases in the concentrations of the total leukocytes, including the agranulocytes. A significant increase in all of the liver function biomarkers except albumin, in lipid profiles except high-density lipoprotein, and in the kidney function markers occurred in the negative control group compared to the rats of the normal control and positive control groups. The coadministration of mushroom extracts significantly ameliorated the toxic effects of the CF. The GL mushroom extract was more efficacious than that of the AP mushroom, possibly due to the presence of high levels of phenolic compounds and other antioxidants in the GL mushroom.
AB - The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran- (CF) induced toxicity in rats. Male Wistar rats (n=42) were divided into six equal groups. The rats in the negative control group received oral administration of CF at 1 mg/kg with the normal diet for 28 days. The treatment groups received oral administration of ethanolic extract of GL or AP at 100 mg/kg followed by coadministration of CF at 1 mg/kg with the normal diet for the same experimental period, respectively. In the CF alone treated group, there were significant decreases in the erythrocytic and thrombocytic indices but increases in the concentrations of the total leukocytes, including the agranulocytes. A significant increase in all of the liver function biomarkers except albumin, in lipid profiles except high-density lipoprotein, and in the kidney function markers occurred in the negative control group compared to the rats of the normal control and positive control groups. The coadministration of mushroom extracts significantly ameliorated the toxic effects of the CF. The GL mushroom extract was more efficacious than that of the AP mushroom, possibly due to the presence of high levels of phenolic compounds and other antioxidants in the GL mushroom.
UR - http://www.scopus.com/inward/record.url?scp=85047785244&partnerID=8YFLogxK
U2 - 10.1155/2018/6254929
DO - 10.1155/2018/6254929
M3 - Article
C2 - 29861774
AN - SCOPUS:85047785244
SN - 1741-427X
VL - 2018
JO - Evidence-Based Complementary and Alternative Medicine
JF - Evidence-Based Complementary and Alternative Medicine
M1 - 6254929
ER -