Gallium reactivates first and second generation quinolone antibiotics towards drug-resistant Klebsiella pneumoniae

Tania Sultana; Rebekah N. Duffin; Victoria L. Blair; Philip C. Andrews

doi:10.1039/d3cc02916f

Gallium reactivates first and second generation quinolone antibiotics towards drug-resistant Klebsiella pneumoniae

Tania Sultana, Rebekah N. Duffin, Victoria L. Blair, Philip C. Andrews

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

Herein, we report on a series of homoleptic [GaL₃] and heteroleptic organometallic [GaMe₂L] complexes of inactive quinolone antibiotics; nalidixic acid, oxolinic acid and norfloxacin with their antibacterial activity (MIC 0.024-0.781 μM) towards four multi-drug resistant strains of Klebsiella pneumoniae through complexation to gallium.

Original language	English
Pages (from-to)	11093-11096
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	74
DOIs	https://doi.org/10.1039/d3cc02916f
Publication status	Published - 21 Nov 2023

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abstract = "Herein, we report on a series of homoleptic [GaL3] and heteroleptic organometallic [GaMe2L] complexes of inactive quinolone antibiotics; nalidixic acid, oxolinic acid and norfloxacin with their antibacterial activity (MIC 0.024-0.781 μM) towards four multi-drug resistant strains of Klebsiella pneumoniae through complexation to gallium.",

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T1 - Gallium reactivates first and second generation quinolone antibiotics towards drug-resistant Klebsiella pneumoniae

AU - Sultana, Tania

AU - Duffin, Rebekah N.

AU - Blair, Victoria L.

AU - Andrews, Philip C.

PY - 2023/11/21

Y1 - 2023/11/21

N2 - Herein, we report on a series of homoleptic [GaL3] and heteroleptic organometallic [GaMe2L] complexes of inactive quinolone antibiotics; nalidixic acid, oxolinic acid and norfloxacin with their antibacterial activity (MIC 0.024-0.781 μM) towards four multi-drug resistant strains of Klebsiella pneumoniae through complexation to gallium.

AB - Herein, we report on a series of homoleptic [GaL3] and heteroleptic organometallic [GaMe2L] complexes of inactive quinolone antibiotics; nalidixic acid, oxolinic acid and norfloxacin with their antibacterial activity (MIC 0.024-0.781 μM) towards four multi-drug resistant strains of Klebsiella pneumoniae through complexation to gallium.

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JO - Chemical Communications

JF - Chemical Communications

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Gallium reactivates first and second generation quinolone antibiotics towards drug-resistant Klebsiella pneumoniae

Abstract

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