Galectin-10, a potential biomarker of eosinophilic airway inflammation

Justin Chua, Jo A Douglass, Andrew Gillman, Robyn E O'Hehir, Els Nicole Theresia Meeusen

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Abstract

Measurement of eosinophilic airway inflammation can assist in the diagnosis of allergic asthma and in the management of exacerbations, however its clinical implementation remains difficult. Galectin-10 has been associated with eosinophilic inflammation and has the potential to be used as a surrogate biomarker. This study aimed to assess the relationship between galectin-10 in sputum with sputum eosinophil counts, the current gold standard of eosinophil inflammation in the lung. Thirty-eight sputum samples were processed for both eosinophil counts by cytospins and semi-quantitative measurements of galectin-10 by western blots. A strong association was observed between galectin-10 levels in sputum and sputum eosinophil measurements, and they accurately determined sputum eosinophilia. The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation.
Original languageEnglish
Article numbere42549
Number of pages6
JournalPLoS ONE
Volume7
Issue number8
DOIs
Publication statusPublished - 2012

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