Abstract
Background: The progressive deterioration of gait in Huntington s disease (HD) leads to functional decline and loss
of function. To understand the underlying mechanisms responsible for the gait changes in HD, we examined the
automatic control of gait by measuring the relationship between stride length and cadence. The relationship is
strongly linked in healthy adults during automatic gait but disrupted in pathological gait disorders, such as
Parkinson?s disease (PD).
Methods: The stride length cadence relationship was compared between seventeen participants with HD, twenty
with PD and twenty one healthy older adults (HOA). Participants had their gait recorded at self-selected preferred,
very slow, slow, fast and very fast speeds. Linear regression analysis was used to determine the slope and intercept
of the relationship which were compared between groups. The adjustment of stride length and cadence when
changing gait speeds was measured and compared within and between groups.
Results: Linearity was strong in all but two participants with HD and one with PD. Slope did not differ between
groups (p > 0.05) but intercept was lower in the HD and PD groups compared to HOA (p <0.05). Stride length was
shorter in the HD and PD groups compared to controls at preferred and most adjusted speed conditions (p <0.05) but
cadence did not differ between groups (p > 0.05) regardless of speed. The HD group adjusted stride length and cadence
similar to HOA when changing speed. The range of cadence across speed conditions did not differ between groups.
Conclusion: Scaling of stride length but not the regulation of cadence was found to be disrupted in participants
with HD.
Original language | English |
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Pages (from-to) | 1 - 8 |
Number of pages | 8 |
Journal | BMC Neurology |
Volume | 14 |
Issue number | 1 (Art. No.: 161) |
DOIs | |
Publication status | Published - 2014 |