Gadolinium(III) spin labels for high-sensitivity distance measurements in transmembrane helices

Erez Matalon, Thomas Huber, Gregor Hagelueken, Bimbil Graham, Veronica Frydman, Akiva Feintuch, Gottfried Otting, Daniella Goldfarb

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High-frequency double electron-electron resonance (DEER) distance measurements using different Gd3+ tags (Gd-DOTA and Gd-C1) were carried out on transmembrane helical peptides (ca. 0.15-nmol; WALP peptides) in a model membrane. The ability to pick up small distance variations, the chemical flexibility of the tags, and the remarkable absolute sensitivity, make this approach attractive for studies of membrane proteins. Copyright ? 2013 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)11831 - 11834
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number45
Publication statusPublished - 2013

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