TY - JOUR
T1 - GABAA receptors and inhibitory neurotransmission in the amygdalar complex
AU - Perumal, Madhusoothanan B.
AU - Lynch, Joseph W.
AU - Sah, Pankaj
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/4
Y1 - 2018/4
N2 - The amygdalar complex (AC) located in the mid-temporal lobe plays a key role in processing emotionally salient information to generate appropriate behavioural output. Inhibitory signalling mediated by GABAergic neurons, and acting through GABAARs within the AC, potently modulates local processing and output of the AC. Disorders of emotional processing such as anxiety and stress, engage the AC, and some of the treatments for these disorders are thought to act via GABAARs receptors in AC. Here we review GABAergic circuits in the AC, the distribution of GABAARs and their putative functional roles through subunit specific GABAARs signalling.
AB - The amygdalar complex (AC) located in the mid-temporal lobe plays a key role in processing emotionally salient information to generate appropriate behavioural output. Inhibitory signalling mediated by GABAergic neurons, and acting through GABAARs within the AC, potently modulates local processing and output of the AC. Disorders of emotional processing such as anxiety and stress, engage the AC, and some of the treatments for these disorders are thought to act via GABAARs receptors in AC. Here we review GABAergic circuits in the AC, the distribution of GABAARs and their putative functional roles through subunit specific GABAARs signalling.
UR - http://www.scopus.com/inward/record.url?scp=85051019199&partnerID=8YFLogxK
U2 - 10.1016/j.cophys.2018.01.003
DO - 10.1016/j.cophys.2018.01.003
M3 - Review Article
AN - SCOPUS:85051019199
SN - 2468-8681
VL - 2
SP - 58
EP - 64
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
ER -