Abstract
G protein-coupled receptors (GPCRs) enable cells to detect and respond to changes in their extracellular environment. With over 800 members, the GPCR family includes receptors for a diverse range of agonists including olfactants, neurotransmitters and hormones. Importantly, GPCRs represent a major therapeutic target, with approximately 50 % of all current drugs acting at some aspect of GPCR signalling (Audet and Bouvier 2008). GPCRs are widely expressed by all cell types in the gastrointestinal (GI) tract and are major regulators of every aspect of gut function. Many GPCRs are internalised upon activation, and this represents one of the mechanisms through which G protein-signalling is terminated. The latency between the endocytosis of GPCRs and their recycling and resensitization is a major determinant of the cell’s ability to respond to subsequent exposure to agonists.
| Original language | English |
|---|---|
| Title of host publication | The Enteric Nervous System |
| Subtitle of host publication | 30 Years Later |
| Editors | Stuart Brierley, Marcello Costa |
| Publisher | Springer |
| Pages | 145-152 |
| Number of pages | 8 |
| ISBN (Electronic) | 978-3-319-27592-5 |
| ISBN (Print) | 978-3-319-27590-1 |
| DOIs | |
| Publication status | Published - 2016 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Publisher | Australian Neuroscience Society |
| Volume | 891 |
| ISSN (Print) | 0065-2598 |
| ISSN (Electronic) | 2214-8019 |
Cite this
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G protein-coupled receptor trafficking and signalling in the enteric nervous system : the past, present and future. / Poole, Daniel P; Bunnett, Nigel W.
The Enteric Nervous System: 30 Years Later. ed. / Stuart Brierley; Marcello Costa. Springer, 2016. p. 145-152 (Advances in Experimental Medicine and Biology; Vol. 891).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
TY - CHAP
T1 - G protein-coupled receptor trafficking and signalling in the enteric nervous system
T2 - the past, present and future
AU - Poole, Daniel P
AU - Bunnett, Nigel W
PY - 2016
Y1 - 2016
N2 - G protein-coupled receptors (GPCRs) enable cells to detect and respond to changes in their extracellular environment. With over 800 members, the GPCR family includes receptors for a diverse range of agonists including olfactants, neurotransmitters and hormones. Importantly, GPCRs represent a major therapeutic target, with approximately 50 % of all current drugs acting at some aspect of GPCR signalling (Audet and Bouvier 2008). GPCRs are widely expressed by all cell types in the gastrointestinal (GI) tract and are major regulators of every aspect of gut function. Many GPCRs are internalised upon activation, and this represents one of the mechanisms through which G protein-signalling is terminated. The latency between the endocytosis of GPCRs and their recycling and resensitization is a major determinant of the cell’s ability to respond to subsequent exposure to agonists.
AB - G protein-coupled receptors (GPCRs) enable cells to detect and respond to changes in their extracellular environment. With over 800 members, the GPCR family includes receptors for a diverse range of agonists including olfactants, neurotransmitters and hormones. Importantly, GPCRs represent a major therapeutic target, with approximately 50 % of all current drugs acting at some aspect of GPCR signalling (Audet and Bouvier 2008). GPCRs are widely expressed by all cell types in the gastrointestinal (GI) tract and are major regulators of every aspect of gut function. Many GPCRs are internalised upon activation, and this represents one of the mechanisms through which G protein-signalling is terminated. The latency between the endocytosis of GPCRs and their recycling and resensitization is a major determinant of the cell’s ability to respond to subsequent exposure to agonists.
UR - http://www.scopus.com/inward/record.url?scp=84992504774&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-27592-5_14
DO - 10.1007/978-3-319-27592-5_14
M3 - Chapter (Book)
SN - 978-3-319-27590-1
T3 - Advances in Experimental Medicine and Biology
SP - 145
EP - 152
BT - The Enteric Nervous System
A2 - Brierley, Stuart
A2 - Costa, Marcello
PB - Springer
ER -