Further characterisation of the Schistosoma japonicum protein Sj23, a target antigen of an immunodiagnostic monoclonal antibody

Kathleen M. Davern, Mark D. Wright, Vanessa R. Herrmann, Graham F. Mitchell

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Sj23, the 23-kDa target antigen in Schistosoma japonicum adult worms of the hybridoma monoclonal antibody (mAb) I-134, has been identified and cloned from cDNA libraries, mAb I-134 has been successfully used in immunodiagnostic assays to detect S. japonicum infection in Philippine patients. Sequence analysis has shown that Sj23 is the homologue, with 84% amino acid identity, of Sm23, a 23-kDa molecule from S. mansoni worms previously described from our laboratory, The domain structures of Sj23 and Sm23 are strikingly similar to the human membrane proteins ME491, CD37, CD53 and TAPA-I. which may suggest a functional role for the schistosome molecules in cellular proliferation.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalMolecular and Biochemical Parasitology
Volume48
Issue number1
DOIs
Publication statusPublished - 1 Jan 1991
Externally publishedYes

Keywords

  • cDNA clone
  • Growth Factor
  • Immunodiagnosis
  • Integral membrane protein
  • Receptor
  • Schistosoma japonicum

Cite this