Fungal Eye Infections: New Hosts, Novel Emerging Pathogens but No New Treatments?

Christina C. Chang, Sharon C.A. Chen

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

Purpose of Review: We sought to explore the current incidence and associated risk factors associated with fungal eye infections. We also reviewed new diagnostic strategies and recent clinical studies exploring the use of topical and oral antifungal agents. Recent Findings: Incidence and associated risks continue to vary with geographic region, and access to timely healthcare. Nosocomial fungal endophthalmitis can result from minor surgical procedures to the eye. Molecular methods offer increasing diagnostic utility. Clinical treatment studies have mainly focussed on the treatment of fungal keratitis and have been conducted in South Asia. Topical natamycin remains superior to topical reconstituted voriconazole and remains the preferred therapy including for Fusarium eye infections. Neither adjunctive oral ketoconazole nor oral voriconazole has been shown to have added clear benefit to topical treatment. Summary: Larger international studies with more heterogenous populations are required for future clinical studies which should include patients with contact lens fungal keratitis and those with fungal endophthalmitis. Basic science studies exploring the immunology of fungal eye infections and drug levels to understand the differences in clinical outcomes are encouraged.

Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalCurrent Fungal Infection Reports
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • Contact lens infection
  • Fungal endophthalmitis
  • Fungal keratitis
  • Invasive fungal infection
  • Mycotic ulcer
  • Topical natamycin
  • Voriconazole

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