Functionalization of microarray devices: process optimization using a multiobjective PSO and multiresponse MARS modeling

Laura Villanova, Paolo Falcaro, Davide Carta, Irene Poli, Robin Hyndman, Kate Smith-Miles

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

3 Citations (Scopus)


An evolutionary approach for the optimization of microarray coatings produced via sol-gel chemistry is presented. The aim of the methodology is to face the challenging aspects of the problem: unknown objective function, high dimensional variable space, constraints on the independent variables, multiple responses, expensive or time-consuming experimental trials, expected complexity of the functional relationships between independent and response variables. The proposed approach iteratively selects a set of experiments by combining a multiob-jective Particle Swarm Optimization (PSO) and a multiresponse Multivariate Adaptive Regression Splines (MARS) model. At each iteration of the algorithm the selected experiments are implemented and evaluated, and the system response is used as a feedback for the selection of the new trials. The performance of the approach is measured in terms of improvements with respect to the best coating obtained changing one variable at a time (the method typically used by scientists). Relevant enhancements have been detected, and the proposed evolutionary approach is shown to be a useful methodology for process optimization with great promise for industrial applications.
Original languageEnglish
Title of host publicationProceedings of the 2010 IEEE Congress on Evolutionary Computation (CEC)
EditorsGary Fogel
Place of PublicationAtlanta USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages1 - 8
Number of pages8
ISBN (Print)9781424469093
Publication statusPublished - 2010
EventIEEE Congress on Evolutionary Computation 2010 - Barcelona, Spain
Duration: 18 Jul 201023 Jul 2010 (Proceedings)


ConferenceIEEE Congress on Evolutionary Computation 2010
Abbreviated titleIEEE CEC 2010
Internet address

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