Functional iron oxide magnetic nanoparticles with hyperthermia-induced drug release ability by using a combination of orthogonal click reactions

Thuy T T N'Guyen, Hien Thi Thu Duong, Johan Sebastian Basuki, Veronique Montembault, Sagrario Galan Pascual, Clement Guibert, Jerome Fresnais, Cyrille Boyer, Michael Raymond Whittaker, Thomas Paul Davis, Laurent Fontaine

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104 Citations (Scopus)

Abstract

Click and drug: A combination of orthogonal click reactions is employed for the preparation of functional iron oxide nanoparticles (IONPs) that show unprecedented hyperthermia-induced drug release through a magnetically stimulated retro-Diels-Alder (rDA) process. Magnetic stimulation induces sufficient local energy in close proximity to the cycloadduct to initiate the rDA process. Copyright ? 2013 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)14152 - 14156
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number52
DOIs
Publication statusPublished - 2013

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