Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis

Alex Fornito, Ben J. Harrison, Emmeline Goodby, Anna M Dean, Cinly Ooi, Pradeep Jonathan Nathan, Belinda R Lennox, Peter Jones, John Suckling, Edward Bullmore

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171 Citations (Scopus)


Dysregulation of corticostriatal circuitry has long been thought to be critical in the etiology of psychotic disorders, although the differential roles played by dorsal and ventral systems in mediating risk for psychosis have been contentious. OBJECTIVE: To use resting-state functional magnetic resonance imaging to characterize disease-related, risk-related, and symptom-related changes of corticostriatal functional circuitry in patients with first-episode psychosis and their unaffected first-degree relatives. DESIGN, SETTING, AND PARTICIPANTS: This case-control cross-sectional study was conducted at a specialist early psychosis clinic, GlaxoSmithKline Clinical Unit, and magnetic resonance imaging facility. Nineteen patients with first-episode psychosis, 25 of their unaffected first-degree relatives, and 26 healthy control subjects were included in this study.
Original languageEnglish
Pages (from-to)1143-1151
Number of pages9
JournalJAMA Psychiatry
Issue number11
Publication statusPublished - Nov 2013

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