Functional division among Monkey prefrontal areas in goal-directed behavior

Keiji Tanaka, Kenji Matsumoto, Farshad A Mansouri, Mark J Buckley

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


The prefrontal cortex (PFC) is thought to play crucial roles in higher cognitive functions, since it has largely evolved in primates. The primate PFC is composed of several areas that differ in their anatomical connections with other brain structures, such as sensory and motor association cortical areas, the basal ganglia, limbic structures, and the hypothalamus (Barbas, 2000; Fuster, 2008; Goldman-Rakic, 1987; Ongur Price, 2000). The functional divisions among prefrontal areas, however, remain largely unknown. We have examined the functional divisions in the primate PFC by comparing neuronal activities and lesion-behavior effects among different prefrontal areas. The elucidation of these functional subdivisions should allow us to understand apparently complicated cognitive functions in terms of more elementary processes. The functional divisions among prefrontal areas are also discussed in other chapters in this book, including Chapter 2, by Fuster; Chapter 14, by Watanabe; and Chapter 6, by Wallis and Kennerley.
Original languageEnglish
Title of host publicationPrinciples of Frontal Lobe Function
EditorsD T Stuss, R T Knight
Place of PublicationUSA
PublisherOxford University Press, USA
Pages1 - 50
Number of pages50
ISBN (Print)978-0-199837-755
Publication statusPublished - 2013
Externally publishedYes

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