Functional Antibodies and Protection against Blood-stage Malaria

Andrew Teo, Gaoqian Feng, Graham V. Brown, James G. Beeson, Stephen J Rogerson

Research output: Contribution to journalReview ArticleOtherpeer-review

61 Citations (Scopus)

Abstract

Numerous efforts to understand the functional roles of antibodies demonstrated that they can protect against malaria. However, it is unclear which antibody responses are the best correlates of immunity, and which antibody functions are most important in protection from disease. Understanding the role of antibodies in protection against malaria is crucial for antimalarial vaccine design. In this review, the specific functional properties of naturally acquired and vaccine-induced antibodies that correlate to protection from the blood stages of Plasmodium falciparum malaria are re-examined and the gaps in knowledge related to antibody function in malarial immunity are highlighted.

Original languageEnglish
Pages (from-to)887-898
Number of pages12
JournalTrends in Parasitology
Volume32
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • antibody
  • immunity
  • naturally acquired
  • Plasmodium falciparum
  • vaccine design

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