Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study

Nellie Georgiou-Karistianis; Govinda Poudel; Juan F Dominguez; Rebecca Langmaid; Marcus Gray; Andrew Churchyard; Phyllis Chua; Beth Borowsky; Gary Francis Egan; Julie C Stout

doi:10.1016/j.bandc.2013.07.004

Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study

Nellie Georgiou-Karistianis, Govinda Poudel, Juan F Dominguez, Rebecca Langmaid, Marcus Gray, Andrew Churchyard, Phyllis Chua, Beth Borowsky, Gary Francis Egan, Julie C Stout

School of Psychological Sciences

Research output: Contribution to journal › Article › Research › peer-review

47 Citations (Scopus)

Abstract

This study aimed to characterize, for the first time, 18. month longitudinal changes in both functional activation and functional connectivity during working memory in premanifest Huntington s disease (pre-HD) and symptomatic HD (symp-HD). Methods: Functional magnetic resonance imaging (fMRI) was used to investigate longitudinal changes in neuronal activity during working memory performance via an N-BACK task (0-BACK and 1-BACK) in 27 pre-HD, 17 symp-HD, and 23 control participants. Whole-brain analysis of activation and region-of-interest analysis of functional connectivity was applied to longitudinal fMRI data collected at baseline and 18. months follow-up.

Original language	English
Pages (from-to)	80 - 91
Number of pages	12
Journal	Brain and Cognition
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/j.bandc.2013.07.004
Publication status	Published - 2013

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10.1016/j.bandc.2013.07.004

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Georgiou-Karistianis, N., Poudel, G., Dominguez, J. F., Langmaid, R., Gray, M., Churchyard, A., Chua, P., Borowsky, B., Egan, G. F., & Stout, J. C. (2013). Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study. Brain and Cognition, 83(1), 80 - 91. https://doi.org/10.1016/j.bandc.2013.07.004

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title = "Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study",

abstract = "This study aimed to characterize, for the first time, 18. month longitudinal changes in both functional activation and functional connectivity during working memory in premanifest Huntington s disease (pre-HD) and symptomatic HD (symp-HD). Methods: Functional magnetic resonance imaging (fMRI) was used to investigate longitudinal changes in neuronal activity during working memory performance via an N-BACK task (0-BACK and 1-BACK) in 27 pre-HD, 17 symp-HD, and 23 control participants. Whole-brain analysis of activation and region-of-interest analysis of functional connectivity was applied to longitudinal fMRI data collected at baseline and 18. months follow-up.",

author = "Nellie Georgiou-Karistianis and Govinda Poudel and Dominguez, {Juan F} and Rebecca Langmaid and Marcus Gray and Andrew Churchyard and Phyllis Chua and Beth Borowsky and Egan, {Gary Francis} and Stout, {Julie C}",

year = "2013",

doi = "10.1016/j.bandc.2013.07.004",

language = "English",

volume = "83",

pages = "80 -- 91",

journal = "Brain and Cognition",

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T1 - Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study

AU - Georgiou-Karistianis, Nellie

AU - Poudel, Govinda

AU - Dominguez, Juan F

AU - Langmaid, Rebecca

AU - Gray, Marcus

AU - Churchyard, Andrew

AU - Chua, Phyllis

AU - Borowsky, Beth

AU - Egan, Gary Francis

AU - Stout, Julie C

PY - 2013

Y1 - 2013

N2 - This study aimed to characterize, for the first time, 18. month longitudinal changes in both functional activation and functional connectivity during working memory in premanifest Huntington s disease (pre-HD) and symptomatic HD (symp-HD). Methods: Functional magnetic resonance imaging (fMRI) was used to investigate longitudinal changes in neuronal activity during working memory performance via an N-BACK task (0-BACK and 1-BACK) in 27 pre-HD, 17 symp-HD, and 23 control participants. Whole-brain analysis of activation and region-of-interest analysis of functional connectivity was applied to longitudinal fMRI data collected at baseline and 18. months follow-up.

AB - This study aimed to characterize, for the first time, 18. month longitudinal changes in both functional activation and functional connectivity during working memory in premanifest Huntington s disease (pre-HD) and symptomatic HD (symp-HD). Methods: Functional magnetic resonance imaging (fMRI) was used to investigate longitudinal changes in neuronal activity during working memory performance via an N-BACK task (0-BACK and 1-BACK) in 27 pre-HD, 17 symp-HD, and 23 control participants. Whole-brain analysis of activation and region-of-interest analysis of functional connectivity was applied to longitudinal fMRI data collected at baseline and 18. months follow-up.

UR - http://www.sciencedirect.com/science/article/pii/S0278262613001000

U2 - 10.1016/j.bandc.2013.07.004

DO - 10.1016/j.bandc.2013.07.004

M3 - Article

VL - 83

SP - 80

EP - 91

JO - Brain and Cognition

JF - Brain and Cognition

SN - 0278-2626

IS - 1

ER -

Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study

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A comparative cognitive and neuroimaging study of pre-diagnosis and symptomatic individuals with Huntington's disease

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Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study

Abstract

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A comparative cognitive and neuroimaging study of pre-diagnosis and symptomatic individuals with Huntington's disease

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