Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study

Nellie Georgiou-Karistianis, Govinda Poudel, Juan F Dominguez, Rebecca Langmaid, Marcus Gray, Andrew Churchyard, Phyllis Chua, Beth Borowsky, Gary Francis Egan, Julie C Stout

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This study aimed to characterize, for the first time, 18. month longitudinal changes in both functional activation and functional connectivity during working memory in premanifest Huntington s disease (pre-HD) and symptomatic HD (symp-HD). Methods: Functional magnetic resonance imaging (fMRI) was used to investigate longitudinal changes in neuronal activity during working memory performance via an N-BACK task (0-BACK and 1-BACK) in 27 pre-HD, 17 symp-HD, and 23 control participants. Whole-brain analysis of activation and region-of-interest analysis of functional connectivity was applied to longitudinal fMRI data collected at baseline and 18. months follow-up.
Original languageEnglish
Pages (from-to)80 - 91
Number of pages12
JournalBrain and Cognition
Issue number1
Publication statusPublished - 2013

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