Projects per year
Abstract
This study aimed to characterize, for the first time, 18. month longitudinal changes in both functional activation and functional connectivity during working memory in premanifest Huntington s disease (pre-HD) and symptomatic HD (symp-HD). Methods: Functional magnetic resonance imaging (fMRI) was used to investigate longitudinal changes in neuronal activity during working memory performance via an N-BACK task (0-BACK and 1-BACK) in 27 pre-HD, 17 symp-HD, and 23 control participants. Whole-brain analysis of activation and region-of-interest analysis of functional connectivity was applied to longitudinal fMRI data collected at baseline and 18. months follow-up.
Original language | English |
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Pages (from-to) | 80 - 91 |
Number of pages | 12 |
Journal | Brain and Cognition |
Volume | 83 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2013 |
Projects
- 1 Finished
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A comparative cognitive and neuroimaging study of pre-diagnosis and symptomatic individuals with Huntington's disease
Georgiou-Karistianis, N., Chiu, E., Churchyard, A., Egan, G. F. & Stout, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/10 → 31/12/13
Project: Research