Function, evolution, and structure of J-domain proteins

Harm H. Kampinga, Claes Andreasson, Alessandro Barducci, Michael E. Cheetham, Douglas Cyr, Cecilia Emanuelsson, Pierre Genevaux, Jason E. Gestwicki, Pierre Goloubinoff, Jaime Huerta-Cepas, Janine Kirstein, Krzysztof Liberek, Matthias P. Mayer, Kazuhiro Nagata, Nadinath B. Nillegoda, Pablo Pulido, Carlos Ramos, Paolo De los Rios, Sabine Rospert, Rina Rosenzweig & 10 others Chandan Sahi, Mikko Taipale, Bratłomiej Tomiczek, Ryo Ushioda, Jason C. Young, Richard Zimmermann, Alicja Zylicz, Maciej Zylicz, Elizabeth A. Craig, Jaroslaw Marszalek

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their facilitation of protein (re)folding, trafficking, remodeling, disaggregation, and degradation. Hsp70 machines are regulated by co-chaperones. J-domain containing proteins (JDPs) are the largest family of Hsp70 co-chaperones and play a determining role functionally specifying and directing Hsp70 functions. Many features of JDPs are not understood; however, a number of JDP experts gathered at a recent CSSI-sponsored workshop in Gdansk (Poland) to discuss various aspects of J-domain protein function, evolution, and structure. In this report, we present the main findings and the consensus reached to help direct future developments in the field of Hsp70 research.

Original languageEnglish
Pages (from-to)7-15
Number of pages9
JournalCell Stress and Chaperones
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 2019

Keywords

  • 8-stranded β-sandwich domain (SBDβ)
  • Heat shock protein 70 (Hsp70)
  • J-domain proteins (JDPs)

Cite this

Kampinga, H. H., Andreasson, C., Barducci, A., Cheetham, M. E., Cyr, D., Emanuelsson, C., ... Marszalek, J. (2019). Function, evolution, and structure of J-domain proteins. Cell Stress and Chaperones, 24(1), 7-15. https://doi.org/10.1007/s12192-018-0948-4
Kampinga, Harm H. ; Andreasson, Claes ; Barducci, Alessandro ; Cheetham, Michael E. ; Cyr, Douglas ; Emanuelsson, Cecilia ; Genevaux, Pierre ; Gestwicki, Jason E. ; Goloubinoff, Pierre ; Huerta-Cepas, Jaime ; Kirstein, Janine ; Liberek, Krzysztof ; Mayer, Matthias P. ; Nagata, Kazuhiro ; Nillegoda, Nadinath B. ; Pulido, Pablo ; Ramos, Carlos ; De los Rios, Paolo ; Rospert, Sabine ; Rosenzweig, Rina ; Sahi, Chandan ; Taipale, Mikko ; Tomiczek, Bratłomiej ; Ushioda, Ryo ; Young, Jason C. ; Zimmermann, Richard ; Zylicz, Alicja ; Zylicz, Maciej ; Craig, Elizabeth A. ; Marszalek, Jaroslaw. / Function, evolution, and structure of J-domain proteins. In: Cell Stress and Chaperones. 2019 ; Vol. 24, No. 1. pp. 7-15.
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Kampinga, HH, Andreasson, C, Barducci, A, Cheetham, ME, Cyr, D, Emanuelsson, C, Genevaux, P, Gestwicki, JE, Goloubinoff, P, Huerta-Cepas, J, Kirstein, J, Liberek, K, Mayer, MP, Nagata, K, Nillegoda, NB, Pulido, P, Ramos, C, De los Rios, P, Rospert, S, Rosenzweig, R, Sahi, C, Taipale, M, Tomiczek, B, Ushioda, R, Young, JC, Zimmermann, R, Zylicz, A, Zylicz, M, Craig, EA & Marszalek, J 2019, 'Function, evolution, and structure of J-domain proteins' Cell Stress and Chaperones, vol. 24, no. 1, pp. 7-15. https://doi.org/10.1007/s12192-018-0948-4

Function, evolution, and structure of J-domain proteins. / Kampinga, Harm H.; Andreasson, Claes; Barducci, Alessandro; Cheetham, Michael E.; Cyr, Douglas; Emanuelsson, Cecilia; Genevaux, Pierre; Gestwicki, Jason E.; Goloubinoff, Pierre; Huerta-Cepas, Jaime; Kirstein, Janine; Liberek, Krzysztof; Mayer, Matthias P.; Nagata, Kazuhiro; Nillegoda, Nadinath B.; Pulido, Pablo; Ramos, Carlos; De los Rios, Paolo; Rospert, Sabine; Rosenzweig, Rina; Sahi, Chandan; Taipale, Mikko; Tomiczek, Bratłomiej; Ushioda, Ryo; Young, Jason C.; Zimmermann, Richard; Zylicz, Alicja; Zylicz, Maciej; Craig, Elizabeth A.; Marszalek, Jaroslaw.

In: Cell Stress and Chaperones, Vol. 24, No. 1, 01.2019, p. 7-15.

Research output: Contribution to journalReview ArticleOtherpeer-review

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AU - Andreasson, Claes

AU - Barducci, Alessandro

AU - Cheetham, Michael E.

AU - Cyr, Douglas

AU - Emanuelsson, Cecilia

AU - Genevaux, Pierre

AU - Gestwicki, Jason E.

AU - Goloubinoff, Pierre

AU - Huerta-Cepas, Jaime

AU - Kirstein, Janine

AU - Liberek, Krzysztof

AU - Mayer, Matthias P.

AU - Nagata, Kazuhiro

AU - Nillegoda, Nadinath B.

AU - Pulido, Pablo

AU - Ramos, Carlos

AU - De los Rios, Paolo

AU - Rospert, Sabine

AU - Rosenzweig, Rina

AU - Sahi, Chandan

AU - Taipale, Mikko

AU - Tomiczek, Bratłomiej

AU - Ushioda, Ryo

AU - Young, Jason C.

AU - Zimmermann, Richard

AU - Zylicz, Alicja

AU - Zylicz, Maciej

AU - Craig, Elizabeth A.

AU - Marszalek, Jaroslaw

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Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C et al. Function, evolution, and structure of J-domain proteins. Cell Stress and Chaperones. 2019 Jan;24(1):7-15. https://doi.org/10.1007/s12192-018-0948-4