Fully biodegradable and biocompatible emulsion templated polymer scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers

David W. Johnson; C. R. Langford; M. P. Didsbury; B. Lipp; S. A. Przyborski; N. R. Cameron

doi:10.1039/c5py00721f

Fully biodegradable and biocompatible emulsion templated polymer scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers

David W. Johnson, C. R. Langford, M. P. Didsbury, B. Lipp, S. A. Przyborski, N. R. Cameron

Materials Science & Engineering

Research output: Contribution to journal › Article › Research › peer-review

65 Citations (Scopus)

Abstract

The emulsion templating process offers a route to highly porous polymers with well-defined morphologies.This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolactone macromonomer. The resulting materialshave nominal porosities of 90% and 95%, and are seen to have an interconnected pore morphology, with an average pore diameter of approximately 60 μm. Initial biocompatibility assessments with fibroblastcells (L929) have shown that the polymers are capable of supporting cell growth over 7 days and degradation products are non-toxic to cells up to a concentration of 0.1 mg ml⁻¹.

Original language	English
Pages (from-to)	7256 - 7263
Number of pages	8
Journal	Polymer Chemistry
Volume	6
Issue number	41
DOIs	https://doi.org/10.1039/c5py00721f
Publication status	Published - 2015

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AU - Lipp, B.

AU - Przyborski, S. A.

AU - Cameron, N. R.

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AB - The emulsion templating process offers a route to highly porous polymers with well-defined morphologies.This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolactone macromonomer. The resulting materialshave nominal porosities of 90% and 95%, and are seen to have an interconnected pore morphology, with an average pore diameter of approximately 60 μm. Initial biocompatibility assessments with fibroblastcells (L929) have shown that the polymers are capable of supporting cell growth over 7 days and degradation products are non-toxic to cells up to a concentration of 0.1 mg ml−1.

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EP - 7263

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JF - Polymer Chemistry

IS - 41

ER -

Fully biodegradable and biocompatible emulsion templated polymer scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers

Abstract

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