Fully biodegradable and biocompatible emulsion templated polymer scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers

David W. Johnson, C. R. Langford, M. P. Didsbury, B. Lipp, S. A. Przyborski, N. R. Cameron

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30 Citations (Scopus)

Abstract

The emulsion templating process offers a route to highly porous polymers with well-defined morphologies.This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolactone macromonomer. The resulting materialshave nominal porosities of 90% and 95%, and are seen to have an interconnected pore morphology, with an average pore diameter of approximately 60 μm. Initial biocompatibility assessments with fibroblastcells (L929) have shown that the polymers are capable of supporting cell growth over 7 days and degradation products are non-toxic to cells up to a concentration of 0.1 mg ml−1.
Original languageEnglish
Pages (from-to)7256 - 7263
Number of pages8
JournalPolymer Chemistry
Volume6
Issue number41
DOIs
Publication statusPublished - 2015

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