Fully automated synthesis of [18F]fluoro-dihydrotestosterone ([18F]FDHT) using the FlexLab module

Uwe Ackermann, Jason S. Lewis, Kenneth Young, Michael J. Morris, Andrew J Weickhardt, Ian D. Davis, Andrew M. Scott

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)


Imaging of androgen receptor expression in prostate cancer using F-18 FDHT is becoming increasingly popular. With the radiolabelling precursor now commercially available, developing a fully automated synthesis of [18F] FDHT is important. We have fully automated the synthesis of F-18 FDHT using the iPhase FlexLab module using only commercially available components. Total synthesis time was 90 min, radiochemical yields were 25-33% (n = 11). Radiochemical purity of the final formulation was > 99% and specific activity was > 18.5 GBq/µmol for all batches. This method can be up-scaled as desired, thus making it possible to study multiple patients in a day. Furthermore, our procedure uses 4 mg of precursor only and is therefore cost-effective. The synthesis has now been validated at Austin Health and is currently used for [18F]FDHT studies in patients. We believe that this method can easily adapted by other modules to further widen the availability of [18F]FDHT.

Original languageEnglish
Pages (from-to)424-428
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number10
Publication statusPublished - 1 Aug 2016

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