Full: Ontogenesis and development of the nonhuman primate pulvinar

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Recent evidence demonstrates that the pulvinar nuclei play a critical role in shaping the connectivity and function of the multiple cortical areas they connect. Surprisingly, however, little is known about the development of this area, the largest corpus of the thalamic nuclei, which go on to occupy 40% of the adult thalamus in the human. It was proposed that the nonhuman primate and the human pulvinar develop according to very different processes, with a greatly reduced neurogenic period in nonhuman primate compared to human and divergent origins. In the marmoset monkey, we demonstrate that neurons populating the pulvinar are generated throughout gestation, suggesting that this aspect of development is more similar to the human than first predicted. While we were able to confirm the diencephalic source of pulvinar neurons, we provide new evidence contesting the presence of an additional niche in the telencephalon. Finally, our study defines new molecular markers that will simplify future investigations in the development and evolution of the pulvinar.

Original languageEnglish
Pages (from-to)2870-2883
Number of pages14
JournalJournal of Comparative Neurology
Volume526
Issue number17
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • development
  • marmoset
  • neurogenesis
  • pulvinar
  • RRID AB_10000347
  • RRID AB_2194626
  • RRID AB_2298772
  • RRID AB_2565003
  • RRID AB_323427
  • thalamus

Cite this

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title = "Full: Ontogenesis and development of the nonhuman primate pulvinar",
abstract = "Recent evidence demonstrates that the pulvinar nuclei play a critical role in shaping the connectivity and function of the multiple cortical areas they connect. Surprisingly, however, little is known about the development of this area, the largest corpus of the thalamic nuclei, which go on to occupy 40{\%} of the adult thalamus in the human. It was proposed that the nonhuman primate and the human pulvinar develop according to very different processes, with a greatly reduced neurogenic period in nonhuman primate compared to human and divergent origins. In the marmoset monkey, we demonstrate that neurons populating the pulvinar are generated throughout gestation, suggesting that this aspect of development is more similar to the human than first predicted. While we were able to confirm the diencephalic source of pulvinar neurons, we provide new evidence contesting the presence of an additional niche in the telencephalon. Finally, our study defines new molecular markers that will simplify future investigations in the development and evolution of the pulvinar.",
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Full : Ontogenesis and development of the nonhuman primate pulvinar. / Homman-Ludiye, Jihane; Kwan, William C.; de Souza, Mitchell J.; Bourne, James A.

In: Journal of Comparative Neurology, Vol. 526, No. 17, 01.12.2018, p. 2870-2883.

Research output: Contribution to journalArticleResearchpeer-review

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