From simultaneous to synergistic MR-PET brain imaging: a review of hybrid MR-PET imaging methodologies

Zhaolin Chen, Sharna Jamadar, Shenpeng Li, Francesco Sforazzini, Jakub Baran, Nicholas Ferris, Nadim Jon Shah, Gary Francis Egan

Research output: Contribution to journalReview ArticleResearchpeer-review

55 Citations (Scopus)


Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simultaneous imaging and the potential for new diagnostic and research capability. This article reviews state-of-the-art MR-PET hardware and software, and discusses future developments focusing on neuroimaging methodologies for MR-PET scanning. We particularly focus on the methodologies that lead to an improved synergy between MRI and PET, including optimal data acquisition, PET attenuation and motion correction, and joint image reconstruction and processing methods based on the underlying complementary and mutual information. We further review the current and potential future applications of simultaneous MR-PET in both systems neuroscience and clinical neuroimaging research. We demonstrate a simultaneous data acquisition protocol to highlight new applications of MR-PET neuroimaging research studies.

Original languageEnglish
Pages (from-to)5126-5144
Number of pages19
JournalHuman Brain Mapping
Issue number12
Publication statusPublished - Dec 2018


  • attenuation correction
  • dynamic FDG-PET
  • functional MRI
  • joint image reconstruction
  • motion
  • MR-PET
  • PET/MR

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