From sewer to saviour-targeting the lymphatic system to promote drug exposure and activity

Natalie Trevaskis, Lisa Michelle Kaminskas, Christopher John Porter

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of metastasis, and recent studies have suggested intrinsic links between lymphatic function, lipid deposition, obesity and atherosclerosis. Advances in the current understanding of the role of the lymphatics in pathological change and immunity have driven the recognition that lymph-targeted delivery has the potential to transform disease treatment and vaccination. In addition, the design of lymphatic delivery systems has progressed from simple systems that rely on passive lymphatic access to sophisticated structures that use nanotechnology to mimic endogenous macromolecules and lipid conjugates that 'hitchhike' onto lipid transport processes. Here, we briefly summarize the lymphatic system in health and disease and the varying mechanisms of lymphatic entry and transport, as well as discussing examples of lymphatic delivery that have enhanced therapeutic utility. We also outline future challenges to effective lymph-directed therapy.
Original languageEnglish
Pages (from-to)781 - 803
Number of pages23
JournalNature Reviews Drug Discovery
Volume14
Issue number11
DOIs
Publication statusPublished - 2015

Cite this

@article{c0f005e814cc4f92a07be9373a69cd5c,
title = "From sewer to saviour-targeting the lymphatic system to promote drug exposure and activity",
abstract = "The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of metastasis, and recent studies have suggested intrinsic links between lymphatic function, lipid deposition, obesity and atherosclerosis. Advances in the current understanding of the role of the lymphatics in pathological change and immunity have driven the recognition that lymph-targeted delivery has the potential to transform disease treatment and vaccination. In addition, the design of lymphatic delivery systems has progressed from simple systems that rely on passive lymphatic access to sophisticated structures that use nanotechnology to mimic endogenous macromolecules and lipid conjugates that 'hitchhike' onto lipid transport processes. Here, we briefly summarize the lymphatic system in health and disease and the varying mechanisms of lymphatic entry and transport, as well as discussing examples of lymphatic delivery that have enhanced therapeutic utility. We also outline future challenges to effective lymph-directed therapy.",
author = "Natalie Trevaskis and Kaminskas, {Lisa Michelle} and Porter, {Christopher John}",
year = "2015",
doi = "10.1038/nrd4608",
language = "English",
volume = "14",
pages = "781 -- 803",
journal = "Nature Reviews Drug Discovery",
issn = "1474-1776",
publisher = "Nature Publishing Group",
number = "11",

}

From sewer to saviour-targeting the lymphatic system to promote drug exposure and activity. / Trevaskis, Natalie; Kaminskas, Lisa Michelle; Porter, Christopher John.

In: Nature Reviews Drug Discovery, Vol. 14, No. 11, 2015, p. 781 - 803.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - From sewer to saviour-targeting the lymphatic system to promote drug exposure and activity

AU - Trevaskis, Natalie

AU - Kaminskas, Lisa Michelle

AU - Porter, Christopher John

PY - 2015

Y1 - 2015

N2 - The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of metastasis, and recent studies have suggested intrinsic links between lymphatic function, lipid deposition, obesity and atherosclerosis. Advances in the current understanding of the role of the lymphatics in pathological change and immunity have driven the recognition that lymph-targeted delivery has the potential to transform disease treatment and vaccination. In addition, the design of lymphatic delivery systems has progressed from simple systems that rely on passive lymphatic access to sophisticated structures that use nanotechnology to mimic endogenous macromolecules and lipid conjugates that 'hitchhike' onto lipid transport processes. Here, we briefly summarize the lymphatic system in health and disease and the varying mechanisms of lymphatic entry and transport, as well as discussing examples of lymphatic delivery that have enhanced therapeutic utility. We also outline future challenges to effective lymph-directed therapy.

AB - The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of metastasis, and recent studies have suggested intrinsic links between lymphatic function, lipid deposition, obesity and atherosclerosis. Advances in the current understanding of the role of the lymphatics in pathological change and immunity have driven the recognition that lymph-targeted delivery has the potential to transform disease treatment and vaccination. In addition, the design of lymphatic delivery systems has progressed from simple systems that rely on passive lymphatic access to sophisticated structures that use nanotechnology to mimic endogenous macromolecules and lipid conjugates that 'hitchhike' onto lipid transport processes. Here, we briefly summarize the lymphatic system in health and disease and the varying mechanisms of lymphatic entry and transport, as well as discussing examples of lymphatic delivery that have enhanced therapeutic utility. We also outline future challenges to effective lymph-directed therapy.

UR - http://www.nature.com.ezproxy.lib.monash.edu.au/nrd/journal/v14/n11/pdf/nrd4608.pdf

U2 - 10.1038/nrd4608

DO - 10.1038/nrd4608

M3 - Article

VL - 14

SP - 781

EP - 803

JO - Nature Reviews Drug Discovery

JF - Nature Reviews Drug Discovery

SN - 1474-1776

IS - 11

ER -