From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis

Denisse L Leyton, Amanda E Rossiter, Ian R Henderson

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

Abstract

Autotransporters are a superfamily of proteins that use the type V secretion pathway for their delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to contain all the functional elements required to promote their own secretion: an amino-terminal signal peptide to mediate translocation across the inner membrane, a central passenger domain that is the secreted functional moiety, and a channel-forming carboxyl terminus that facilitates passenger domain translocation across the outer membrane. However, recent discoveries of common structural themes, translocation intermediates and accessory interactions have challenged the perceived simplicity of autotransporter secretion. Here, we discuss how these studies have led to an improved understanding of the mechanisms responsible for autotransporter biogenesis.
Original languageEnglish
Pages (from-to)213 - 225
Number of pages13
JournalNature Reviews Microbiology
Volume10
Issue number3
DOIs
Publication statusPublished - 2012

Cite this

Leyton, Denisse L ; Rossiter, Amanda E ; Henderson, Ian R. / From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis. In: Nature Reviews Microbiology. 2012 ; Vol. 10, No. 3. pp. 213 - 225.
@article{ba4ed7c2da134a8f80fd60bc99c2c506,
title = "From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis",
abstract = "Autotransporters are a superfamily of proteins that use the type V secretion pathway for their delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to contain all the functional elements required to promote their own secretion: an amino-terminal signal peptide to mediate translocation across the inner membrane, a central passenger domain that is the secreted functional moiety, and a channel-forming carboxyl terminus that facilitates passenger domain translocation across the outer membrane. However, recent discoveries of common structural themes, translocation intermediates and accessory interactions have challenged the perceived simplicity of autotransporter secretion. Here, we discuss how these studies have led to an improved understanding of the mechanisms responsible for autotransporter biogenesis.",
author = "Leyton, {Denisse L} and Rossiter, {Amanda E} and Henderson, {Ian R}",
year = "2012",
doi = "10.1038/nrmicro2733",
language = "English",
volume = "10",
pages = "213 -- 225",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "3",

}

From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis. / Leyton, Denisse L; Rossiter, Amanda E; Henderson, Ian R.

In: Nature Reviews Microbiology, Vol. 10, No. 3, 2012, p. 213 - 225.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis

AU - Leyton, Denisse L

AU - Rossiter, Amanda E

AU - Henderson, Ian R

PY - 2012

Y1 - 2012

N2 - Autotransporters are a superfamily of proteins that use the type V secretion pathway for their delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to contain all the functional elements required to promote their own secretion: an amino-terminal signal peptide to mediate translocation across the inner membrane, a central passenger domain that is the secreted functional moiety, and a channel-forming carboxyl terminus that facilitates passenger domain translocation across the outer membrane. However, recent discoveries of common structural themes, translocation intermediates and accessory interactions have challenged the perceived simplicity of autotransporter secretion. Here, we discuss how these studies have led to an improved understanding of the mechanisms responsible for autotransporter biogenesis.

AB - Autotransporters are a superfamily of proteins that use the type V secretion pathway for their delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to contain all the functional elements required to promote their own secretion: an amino-terminal signal peptide to mediate translocation across the inner membrane, a central passenger domain that is the secreted functional moiety, and a channel-forming carboxyl terminus that facilitates passenger domain translocation across the outer membrane. However, recent discoveries of common structural themes, translocation intermediates and accessory interactions have challenged the perceived simplicity of autotransporter secretion. Here, we discuss how these studies have led to an improved understanding of the mechanisms responsible for autotransporter biogenesis.

UR - http://www.nature.com/nrmicro/journal/v10/n3/pdf/nrmicro2733.pdf

U2 - 10.1038/nrmicro2733

DO - 10.1038/nrmicro2733

M3 - Article

VL - 10

SP - 213

EP - 225

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 3

ER -