From embryonic stem cells to testicular germ cell cancer - Should we be concerned?

Kristian Almstrup, Si Brask Sonne, Christina E. Hoei-Hansen, Anne Marie Ottesen, John E. Nielsen, Niels E. Skakkebæk, Henrik Leffers, Ewa Rajpert De Meyts

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

Since the discovery of testicular carcinoma in situ (CIS) - the precursor cell for the vast majority of germ cell tumours - it has been proposed that CIS cells could be derived from transformed primordial germ cells or gonocytes. Here, we review recent discoveries not only substantiating that initial hypothesis but also indicating that CIS cells have a striking phenotypic similarity to embryonic stem cells (ESC). Many cancers have been proposed to originate from tissue-specific stem cells [so-called 'cancer stem cells' (CSC)] and we argue that CIS may be a very good example of a CSC, but with exceptional features due to the retention of embryonic pluripotency. In addition, considering the fact that pre-invasive CIS cells are transformed from early fetal cells, possibly due to environmentally induced alterations of the niche, we discuss potential risks linked to the uncontrolled therapeutic use of ESC.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalInternational Journal of Andrology
Volume29
Issue number1
DOIs
Publication statusPublished - 1 Feb 2006
Externally publishedYes

Keywords

  • Cancer stem cells
  • Carcinoma in situ
  • Embryonic stem cells
  • Testicular germ cell cancers

Cite this

Almstrup, K., Sonne, S. B., Hoei-Hansen, C. E., Ottesen, A. M., Nielsen, J. E., Skakkebæk, N. E., ... Meyts, E. R. D. (2006). From embryonic stem cells to testicular germ cell cancer - Should we be concerned? International Journal of Andrology, 29(1), 211-218. https://doi.org/10.1111/j.1365-2605.2005.00643.x
Almstrup, Kristian ; Sonne, Si Brask ; Hoei-Hansen, Christina E. ; Ottesen, Anne Marie ; Nielsen, John E. ; Skakkebæk, Niels E. ; Leffers, Henrik ; Meyts, Ewa Rajpert De. / From embryonic stem cells to testicular germ cell cancer - Should we be concerned?. In: International Journal of Andrology. 2006 ; Vol. 29, No. 1. pp. 211-218.
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Almstrup, K, Sonne, SB, Hoei-Hansen, CE, Ottesen, AM, Nielsen, JE, Skakkebæk, NE, Leffers, H & Meyts, ERD 2006, 'From embryonic stem cells to testicular germ cell cancer - Should we be concerned?', International Journal of Andrology, vol. 29, no. 1, pp. 211-218. https://doi.org/10.1111/j.1365-2605.2005.00643.x

From embryonic stem cells to testicular germ cell cancer - Should we be concerned? / Almstrup, Kristian; Sonne, Si Brask; Hoei-Hansen, Christina E.; Ottesen, Anne Marie; Nielsen, John E.; Skakkebæk, Niels E.; Leffers, Henrik; Meyts, Ewa Rajpert De.

In: International Journal of Andrology, Vol. 29, No. 1, 01.02.2006, p. 211-218.

Research output: Contribution to journalArticleResearchpeer-review

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Almstrup K, Sonne SB, Hoei-Hansen CE, Ottesen AM, Nielsen JE, Skakkebæk NE et al. From embryonic stem cells to testicular germ cell cancer - Should we be concerned? International Journal of Andrology. 2006 Feb 1;29(1):211-218. https://doi.org/10.1111/j.1365-2605.2005.00643.x