Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Improvements in vitrification now make frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that: (i) the endometrium in stimulated cycles is not optimally prepared for implantation; (ii) pregnancy rates are increased following FET and (iii) perinatal outcomes are less affected after FET. METHODS: This review integrates and discusses the available clinical and scientific evidence supporting embryo transfer in a natural cycle. RESULTS: Laboratory-based studies demonstrate morphological and molecular changes to the endometrium and reduced responsiveness of the endometrium to hCG, resulting from controlled ovarian stimulation. The literature demonstrates reduced endometrial receptivity in controlled ovarian stimulation cycles and supports the clinical observations that FET reduces the risk of ovarian hyperstimulation syndrome and improves outcomes for both the mother and baby. CONCLUSIONS: This review provides the basis for an evidence-based approach towards changes in routine IVF, which may ultimately result in higher delivery rates of healthier term babies.
Original languageEnglish
Pages (from-to)808 - 821
Number of pages14
JournalHuman Reproduction Update
Volume20
Issue number6 (Art. ID: dmu027)
DOIs
Publication statusPublished - 2014

Cite this

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title = "Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence",
abstract = "Improvements in vitrification now make frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that: (i) the endometrium in stimulated cycles is not optimally prepared for implantation; (ii) pregnancy rates are increased following FET and (iii) perinatal outcomes are less affected after FET. METHODS: This review integrates and discusses the available clinical and scientific evidence supporting embryo transfer in a natural cycle. RESULTS: Laboratory-based studies demonstrate morphological and molecular changes to the endometrium and reduced responsiveness of the endometrium to hCG, resulting from controlled ovarian stimulation. The literature demonstrates reduced endometrial receptivity in controlled ovarian stimulation cycles and supports the clinical observations that FET reduces the risk of ovarian hyperstimulation syndrome and improves outcomes for both the mother and baby. CONCLUSIONS: This review provides the basis for an evidence-based approach towards changes in routine IVF, which may ultimately result in higher delivery rates of healthier term babies.",
author = "Jemma Evans and Hannan, {Natalie Josephine} and Tracey Edgell and Vollenhoven, {Beverley Janine} and Peter Lutjen and Tiki Osianlis and Salamonsen, {Lois A} and Luk Rombauts",
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language = "English",
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journal = "Human Reproduction Update",
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Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence. / Evans, Jemma; Hannan, Natalie Josephine; Edgell, Tracey; Vollenhoven, Beverley Janine; Lutjen, Peter; Osianlis, Tiki; Salamonsen, Lois A; Rombauts, Luk.

In: Human Reproduction Update, Vol. 20, No. 6 (Art. ID: dmu027), 2014, p. 808 - 821.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence

AU - Evans, Jemma

AU - Hannan, Natalie Josephine

AU - Edgell, Tracey

AU - Vollenhoven, Beverley Janine

AU - Lutjen, Peter

AU - Osianlis, Tiki

AU - Salamonsen, Lois A

AU - Rombauts, Luk

PY - 2014

Y1 - 2014

N2 - Improvements in vitrification now make frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that: (i) the endometrium in stimulated cycles is not optimally prepared for implantation; (ii) pregnancy rates are increased following FET and (iii) perinatal outcomes are less affected after FET. METHODS: This review integrates and discusses the available clinical and scientific evidence supporting embryo transfer in a natural cycle. RESULTS: Laboratory-based studies demonstrate morphological and molecular changes to the endometrium and reduced responsiveness of the endometrium to hCG, resulting from controlled ovarian stimulation. The literature demonstrates reduced endometrial receptivity in controlled ovarian stimulation cycles and supports the clinical observations that FET reduces the risk of ovarian hyperstimulation syndrome and improves outcomes for both the mother and baby. CONCLUSIONS: This review provides the basis for an evidence-based approach towards changes in routine IVF, which may ultimately result in higher delivery rates of healthier term babies.

AB - Improvements in vitrification now make frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that: (i) the endometrium in stimulated cycles is not optimally prepared for implantation; (ii) pregnancy rates are increased following FET and (iii) perinatal outcomes are less affected after FET. METHODS: This review integrates and discusses the available clinical and scientific evidence supporting embryo transfer in a natural cycle. RESULTS: Laboratory-based studies demonstrate morphological and molecular changes to the endometrium and reduced responsiveness of the endometrium to hCG, resulting from controlled ovarian stimulation. The literature demonstrates reduced endometrial receptivity in controlled ovarian stimulation cycles and supports the clinical observations that FET reduces the risk of ovarian hyperstimulation syndrome and improves outcomes for both the mother and baby. CONCLUSIONS: This review provides the basis for an evidence-based approach towards changes in routine IVF, which may ultimately result in higher delivery rates of healthier term babies.

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