Frequency of the New HLA-B*2709 Allele in Ankylosing Spondylitis Patients and Healthy Individuals

Mauro D'Amato, Maria T Fiorillo, Mauro Galeazzi, Miriam Martinetti, Antonio Amoroso, Rosa Sorrentino

Research output: Contribution to journalLetterOtherpeer-review


We have recently described a new HLA-B27 subtype, named HLA-B*2709 (DelPorto et al. 1994). This allele is identical to the subtype most frequently found in Caucasoids, HLA-B*2705, except for a single amino acid substitution (Asp to His) in position 116. This residue, that is part of the F pocket of the molecule, has been shown to be relevant in determining which C-terminal amino acid of HLA-class I-binding peptides can be accomodated into the groove (Elliott, 1993). In nonamer peptides, this amino acid corresponds to a primary anchor position (P9; Madden et aI., 1992). Accordingly, we have previously shown that B2709 molecule hardly accepts nonamer peptides with an Arg or Tyr in P9, while the same amino acids represent good anchors for B2705 molecules (Fiorillo et aI. , 1995).
Original languageEnglish
Pages (from-to)215-217
Number of pages3
JournalDisease Markers
Issue number3
Publication statusPublished - 1994

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