TY - JOUR
T1 - Frequency of fatigue and its changes in the first 6 months after traumatic brain injury
T2 - results from the CENTER-TBI study
AU - Andelic, Nada
AU - Roe, Cecilie
AU - Brunborg, Cathrine
AU - Zeldovich, Marina
AU - Løvstad, Marianne
AU - Løke, Daniel
AU - Borgen, Ida M.
AU - Voormolen, Daphne C.
AU - Howe, Emilie I.
AU - Forslund, Marit V.
AU - Dahl, Hilde M.
AU - von Steinbuechel, Nicole
AU - Åkerlund, Cecilia
AU - Amrein, Krisztina
AU - Andelic, Nada
AU - Andreassen, Lasse
AU - Anke, Audny
AU - Antoni, Anna
AU - Audibert, Gérard
AU - Azouvi, Philippe
AU - Azzolini, Maria Luisa
AU - Bartels, Ronald
AU - Barzó, Pál
AU - Beauvais, Romuald
AU - Beer, Ronny
AU - Bellander, Bo Michael
AU - Belli, Antonio
AU - Benali, Habib
AU - Berardino, Maurizio
AU - Beretta, Luigi
AU - Blaabjerg, Morten
AU - Bragge, Peter
AU - Brazinova, Alexandra
AU - Brinck, Vibeke
AU - Brooker, Joanne
AU - Brorsson, Camilla
AU - Buki, Andras
AU - Bullinger, Monika
AU - Cabeleira, Manuel
AU - Caccioppola, Alessio
AU - Calappi, Emiliana
AU - Calvi, Maria Rosa
AU - Cameron, Peter
AU - Lozano, Guillermo Carbayo
AU - Carbonara, Marco
AU - Cavallo, Simona
AU - Chevallard, Giorgio
AU - Chieregato, Arturo
AU - Citerio, Giuseppe
AU - Ceyisakar, Iris
AU - Clusmann, Hans
AU - Coburn, Mark
AU - Coles, Jonathan
AU - Cooper, Jamie D.
AU - Correia, Marta
AU - Čović, Amra
AU - Curry, Nicola
AU - Czeiter, Endre
AU - Czosnyka, Marek
AU - Dahyot-Fizelier, Claire
AU - Dark, Paul
AU - Dawes, Helen
AU - Keyser, Véronique
AU - Degos, Vincent
AU - Corte, Francesco Della
AU - Boogert, Hugo
AU - Depreitere, Bart
AU - Đilvesi, Đula
AU - Dixit, Abhishek
AU - Donoghue, Emma
AU - Dreier, Jens
AU - Dulière, Guy Loup
AU - Ercole, Ari
AU - Esser, Patrick
AU - Ezer, Erzsébet
AU - Fabricius, Martin
AU - Feigin, Valery L.
AU - Foks, Kelly
AU - Frisvold, Shirin
AU - Furmanov, Alex
AU - Gagliardo, Pablo
AU - Galanaud, Damien
AU - Gantner, Dashiell
AU - Gao, Guoyi
AU - George, Pradeep
AU - Ghuysen, Alexandre
AU - Giga, Lelde
AU - Glocker, Ben
AU - Golubovic, Jagoš
AU - Gomez, Pedro A.
AU - Gratz, Johannes
AU - Gravesteijn, Benjamin
AU - Grossi, Francesca
AU - Gruen, Russell L.
AU - Gupta, Deepak
AU - Haagsma, Juanita A.
AU - Haitsma, Iain
AU - Helbok, Raimund
AU - Helseth, Eirik
AU - Horton, Lindsay
AU - Huijben, Jilske
AU - Hutchinson, Peter J.
AU - Jacobs, Bram
AU - Jankowski, Stefan
AU - Jarrett, Mike
AU - Jiang, Ji yao
AU - Johnson, Faye
AU - Jones, Kelly
AU - Karan, Mladen
AU - Kolias, Angelos G.
AU - Kompanje, Erwin
AU - Kondziella, Daniel
AU - Koraropoulos, Evgenios
AU - Koskinen, Lars Owe
AU - Kovács, Noémi
AU - Kowark, Ana
AU - Lagares, Alfonso
AU - Lanyon, Linda
AU - Laureys, Steven
AU - Lecky, Fiona
AU - Ledoux, Didier
AU - Lefering, Rolf
AU - Legrand, Valerie
AU - Lejeune, Aurelie
AU - Levi, Leon
AU - Lightfoot, Roger
AU - Lingsma, Hester
AU - Maas, Andrew I.R.
AU - Castaño-León, Ana M.
AU - Maegele, Marc
AU - Majdan, Marek
AU - Manara, Alex
AU - Manley, Geoffrey
AU - Martino, Costanza
AU - Maréchal, Hugues
AU - Mattern, Julia
AU - McMahon, Catherine
AU - Melegh, Béla
AU - Menon, David
AU - Menovsky, Tomas
AU - Mikolic, Ana
AU - Misset, Benoit
AU - Muraleedharan, Visakh
AU - Murray, Lynnette
AU - Negru, Ancuta
AU - Nelson, David
AU - Newcombe, Virginia
AU - Nieboer, Daan
AU - Nyirádi, József
AU - Olubukola, Otesile
AU - Oresic, Matej
AU - Ortolano, Fabrizio
AU - Palotie, Aarno
AU - Parizel, Paul M.
AU - Payen, Jean François
AU - Perera, Natascha
AU - Perlbarg, Vincent
AU - Persona, Paolo
AU - Peul, Wilco
AU - Piippo-Karjalainen, Anna
AU - Pirinen, Matti
AU - Ples, Horia
AU - Polinder, Suzanne
AU - Pomposo, Inigo
AU - Posti, Jussi P.
AU - Puybasset, Louis
AU - Radoi, Andreea
AU - Ragauskas, Arminas
AU - Raj, Rahul
AU - Rambadagalla, Malinka
AU - Rhodes, Jonathan
AU - Richardson, Sylvia
AU - Richter, Sophie
AU - Ripatti, Samuli
AU - Rocka, Saulius
AU - Roe, Cecilie
AU - Roise, Olav
AU - Rosand, Jonathan
AU - Rosenfeld, Jeffrey V.
AU - Rosenlund, Christina
AU - Rosenthal, Guy
AU - Rossaint, Rolf
AU - Rossi, Sandra
AU - Rueckert, Daniel
AU - Rusnák, Martin
AU - Sahuquillo, Juan
AU - Sakowitz, Oliver
AU - Sanchez-Porras, Renan
AU - Sandor, Janos
AU - Schäfer, Nadine
AU - Schmidt, Silke
AU - Schoechl, Herbert
AU - Schoonman, Guus
AU - Schou, Rico Frederik
AU - Schwendenwein, Elisabeth
AU - Sewalt, Charlie
AU - Skandsen, Toril
AU - Smielewski, Peter
AU - Sorinola, Abayomi
AU - Stamatakis, Emmanuel
AU - Stanworth, Simon
AU - Stevens, Robert
AU - Stewart, William
AU - Steyerberg, Ewout W.
AU - Stocchetti, Nino
AU - Sundström, Nina
AU - Synnot, Anneliese
AU - Takala, Riikka
AU - Tamás, Viktória
AU - Tamosuitis, Tomas
AU - Taylor, Mark Steven
AU - Ao, Braden Te
AU - Tenovuo, Olli
AU - Theadom, Alice
AU - Thomas, Matt
AU - Tibboel, Dick
AU - Timmers, Marjolein
AU - Tolias, Christos
AU - Trapani, Tony
AU - Maria Tudora, Cristina
AU - Vajkoczy, Peter
AU - Vallance, Shirley
AU - Valeinis, Egils
AU - Vámos, Zoltán
AU - Jagt, Mathieu
AU - Steen, Gregory
AU - van der Naalt, Joukje
AU - Jeroen, T. J.M.van Dijck
AU - Essen, Thomas A.
AU - Hecke, Wim
AU - Heugten, Caroline
AU - Praag, Dominique
AU - Vyvere, Thijs
AU - RoelWijk, P. J.
AU - Vargiolu, Alessia
AU - Vega, Emmanuel
AU - Velt, Kimberley
AU - Verheyden, Jan
AU - Vespa, Paul M.
AU - Vik, Anne
AU - Vilcinis, Rimantas
AU - Volovici, Victor
AU - Steinbüchel, Nicole
AU - Voormolen, Daphne
AU - Vulekovic, Petar
AU - Wang, Kevin K.W.
AU - Wiegers, Eveline
AU - Williams, Guy
AU - Wilson, Lindsay
AU - Winzeck, Stefan
AU - CENTER TBI Participants and Investigators
PY - 2021
Y1 - 2021
N2 - Background: Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. Methods: Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subjective fatigue was measured by single item on the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), administered at baseline, three and 6 months postinjury. Patients were categorized by clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU). Injury severity, preinjury somatic- and psychiatric conditions, depressive and sleep problems were registered at baseline. For prediction of fatigue changes, descriptive statistics and mixed effect logistic regression analysis are reported. Results: Fatigue was experienced by 47% of patients at baseline, 48% at 3 months and 46% at 6 months. Patients admitted to ICU had a higher probability of experiencing fatigue than those in ER and ADM strata. Females and individuals with lower age, higher education, more severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance and feeling depressed postinjury had a higher probability of fatigue. Conclusion: A high and stable frequency of fatigue was found during the first 6 months after TBI. Specific socio-demographic factors, comorbidities and injury severity characteristics were predictors of fatigue in this study.
AB - Background: Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. Methods: Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subjective fatigue was measured by single item on the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), administered at baseline, three and 6 months postinjury. Patients were categorized by clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU). Injury severity, preinjury somatic- and psychiatric conditions, depressive and sleep problems were registered at baseline. For prediction of fatigue changes, descriptive statistics and mixed effect logistic regression analysis are reported. Results: Fatigue was experienced by 47% of patients at baseline, 48% at 3 months and 46% at 6 months. Patients admitted to ICU had a higher probability of experiencing fatigue than those in ER and ADM strata. Females and individuals with lower age, higher education, more severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance and feeling depressed postinjury had a higher probability of fatigue. Conclusion: A high and stable frequency of fatigue was found during the first 6 months after TBI. Specific socio-demographic factors, comorbidities and injury severity characteristics were predictors of fatigue in this study.
KW - Head injury
KW - Longitudinal studies
KW - Neurological disorders
KW - Post-traumatic fatigue
UR - http://www.scopus.com/inward/record.url?scp=85088051993&partnerID=8YFLogxK
U2 - 10.1007/s00415-020-10022-2
DO - 10.1007/s00415-020-10022-2
M3 - Article
C2 - 32676767
AN - SCOPUS:85088051993
VL - 268
SP - 61
EP - 73
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
ER -