Frequency distribution of TATA box and extension sequences on human promoters

Shi Wei; Zhou Wanlei

doi:10.1109/IMSCCS.2006.70

Frequency distribution of TATA box and extension sequences on human promoters

Shi Wei
, Zhou Wanlei

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other › peer-review

Abstract

TATA box is one of the most important transcription factor binding sites. But the exact sequences of TATA box are still not very clear yet. In this study, we conducted a dedicated analysis on the frequency distribution of TA TA Box and its extension sequences on human promoters. Sixteen TATA elements derived from TATA Box. motif, TATAWAWN, were classified into three distribution patterns: peak, bottom-peak and bottom. Fourteen TA TA extension sequences (up to two base extensions) were predicted to be the new TATA Box elements because of their high motif factors, which indicate their statistical significance. Statistical analysis on the promoters of mouse, zebrafish and drosophila melanogaster verified seven of these elements. It was also observed that the distribution of TATA elements on the promoters of housekeeping genes are very similar with their distribution on the promoters of tissue specific genes in human.

Original language	English
Title of host publication	International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06)
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	3-9
Number of pages	7
ISBN (Print)	0769525814, 9780769525815
DOIs	https://doi.org/10.1109/IMSCCS.2006.70
Publication status	Published - 2006
Externally published	Yes
Event	International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06) - Hangzhou, Zhejiang, China Duration: 20 Apr 2006 → 24 Apr 2006 Conference number: 1st https://ieeexplore.ieee.org/xpl/conhome/10901/proceeding

Conference

Conference	International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06)
Abbreviated title	IMSCCS'06
Country/Territory	China
City	Hangzhou, Zhejiang
Period	20/04/06 → 24/04/06
Internet address	https://ieeexplore.ieee.org/xpl/conhome/10901/proceeding

Access to Document

10.1109/IMSCCS.2006.70

Cite this

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title = "Frequency distribution of TATA box and extension sequences on human promoters",

abstract = "TATA box is one of the most important transcription factor binding sites. But the exact sequences of TATA box are still not very clear yet. In this study, we conducted a dedicated analysis on the frequency distribution of TA TA Box and its extension sequences on human promoters. Sixteen TATA elements derived from TATA Box. motif, TATAWAWN, were classified into three distribution patterns: peak, bottom-peak and bottom. Fourteen TA TA extension sequences (up to two base extensions) were predicted to be the new TATA Box elements because of their high motif factors, which indicate their statistical significance. Statistical analysis on the promoters of mouse, zebrafish and drosophila melanogaster verified seven of these elements. It was also observed that the distribution of TATA elements on the promoters of housekeeping genes are very similar with their distribution on the promoters of tissue specific genes in human.",

author = "Shi Wei and Zhou Wanlei",

year = "2006",

doi = "10.1109/IMSCCS.2006.70",

language = "English",

isbn = "0769525814",

pages = "3--9",

booktitle = "International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06)",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

address = "United States of America",

note = "International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06), IMSCCS'06 ; Conference date: 20-04-2006 Through 24-04-2006",

url = "https://ieeexplore.ieee.org/xpl/conhome/10901/proceeding",

}

Wei, S & Wanlei, Z 2006, Frequency distribution of TATA box and extension sequences on human promoters. in International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06)., 1636010, IEEE, Institute of Electrical and Electronics Engineers, pp. 3-9, International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06), Hangzhou, Zhejiang, China, 20/04/06. https://doi.org/10.1109/IMSCCS.2006.70

Frequency distribution of TATA box and extension sequences on human promoters. / Wei, Shi; Wanlei, Zhou.
International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06). IEEE, Institute of Electrical and Electronics Engineers, 2006. p. 3-9 1636010.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other › peer-review

TY - GEN

T1 - Frequency distribution of TATA box and extension sequences on human promoters

AU - Wei, Shi

AU - Wanlei, Zhou

N1 - Conference code: 1st

PY - 2006

Y1 - 2006

N2 - TATA box is one of the most important transcription factor binding sites. But the exact sequences of TATA box are still not very clear yet. In this study, we conducted a dedicated analysis on the frequency distribution of TA TA Box and its extension sequences on human promoters. Sixteen TATA elements derived from TATA Box. motif, TATAWAWN, were classified into three distribution patterns: peak, bottom-peak and bottom. Fourteen TA TA extension sequences (up to two base extensions) were predicted to be the new TATA Box elements because of their high motif factors, which indicate their statistical significance. Statistical analysis on the promoters of mouse, zebrafish and drosophila melanogaster verified seven of these elements. It was also observed that the distribution of TATA elements on the promoters of housekeeping genes are very similar with their distribution on the promoters of tissue specific genes in human.

AB - TATA box is one of the most important transcription factor binding sites. But the exact sequences of TATA box are still not very clear yet. In this study, we conducted a dedicated analysis on the frequency distribution of TA TA Box and its extension sequences on human promoters. Sixteen TATA elements derived from TATA Box. motif, TATAWAWN, were classified into three distribution patterns: peak, bottom-peak and bottom. Fourteen TA TA extension sequences (up to two base extensions) were predicted to be the new TATA Box elements because of their high motif factors, which indicate their statistical significance. Statistical analysis on the promoters of mouse, zebrafish and drosophila melanogaster verified seven of these elements. It was also observed that the distribution of TATA elements on the promoters of housekeeping genes are very similar with their distribution on the promoters of tissue specific genes in human.

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DO - 10.1109/IMSCCS.2006.70

M3 - Conference Paper

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SN - 0769525814

SN - 9780769525815

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BT - International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06)

PB - IEEE, Institute of Electrical and Electronics Engineers

T2 - International Multi- Symposiums on Computer and Computational Sciences (IMSCCS'06)

Y2 - 20 April 2006 through 24 April 2006

ER -

Frequency distribution of TATA box and extension sequences on human promoters

Abstract

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Frequency distribution of TATA Box and extension sequences on human promoters

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