Frequency and significance of qSOFA criteria during adult rapid response team reviews: A prospective cohort study

Maurice LeGuen; Yvonne Ballueer; Richard McKay; Glenn Eastwood; Rinaldo Bellomo; Daryl Jones; The Austin Health RRT qSOFA investigators; Michelle Topple; Tammie McIntyre; Carmel Taylor; Damien Blythe; Brooke Ryan; Najeea Ali; Toby Jeffcote; Sadie O’Callahan; Mark Kubicki; Neil Glassford; Boris Tseitkin; Timothy Ho; Wisam Al-Bassam; Rahul Costa-Pinto; Kelvin Kuik; Scott May; Jeremy Broad; Chuan Tai Foo; Michelle Grigoriadis; James Bennett; Karen McCrohan; Melissa Gloster; Merryn Barker; Mary Larsen; William Tui; Cathy Young; Clair Osborne; Sandra Moore; Brian Shortal; Penny Ashworth; Lisa Fuhrmeister; Craig Lesom; Tony King; Alison Rose; Robyn Best; Kristy Ross; Lyndal Fawcett; Meagan Delaney; Melissa Butterworth; Melisa Bu; Been Cherian; Jayne Ramsdale; Renee Bartlett; Carmel Walsh; Kate Dixon; Abbey Littlepage; Valerie Liambos; Margaret Holley; Catherine Campbell; Deirdre Nion; Michelle Baxter; Mee Cheng; Monica Dowling; Craig Elsom

doi:10.1016/j.resuscitation.2017.11.036

Frequency and significance of qSOFA criteria during adult rapid response team reviews: A prospective cohort study

Maurice LeGuen, Yvonne Ballueer, Richard McKay, Glenn Eastwood, Rinaldo Bellomo, Daryl Jones, The Austin Health RRT qSOFA investigators, Michelle Topple, Tammie McIntyre, Carmel Taylor, Damien Blythe, Brooke Ryan, Najeea Ali, Toby Jeffcote, Sadie O’Callahan, Mark Kubicki, Neil Glassford, Boris Tseitkin, Timothy Ho, Wisam Al-BassamRahul Costa-Pinto, Kelvin Kuik, Scott May, Jeremy Broad, Chuan Tai Foo, Michelle Grigoriadis, James Bennett, Karen McCrohan, Melissa Gloster, Merryn Barker, Mary Larsen, William Tui, Cathy Young, Clair Osborne, Sandra Moore, Brian Shortal, Penny Ashworth, Lisa Fuhrmeister, Craig Lesom, Tony King, Alison Rose, Robyn Best, Kristy Ross, Lyndal Fawcett, Meagan Delaney, Melissa Butterworth, Melisa Bu, Been Cherian, Jayne Ramsdale, Renee Bartlett, Carmel Walsh, Kate Dixon, Abbey Littlepage, Valerie Liambos, Margaret Holley, Catherine Campbell, Deirdre Nion, Michelle Baxter, Mee Cheng, Monica Dowling, Craig Elsom

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Aim A new definition of sepsis released by an international task-force has introduced the concept of quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA). This study aimed to measure the proportion of patients who fulfilled qSOFA criteria during a Rapid Response Team (RRT) review and to assess their associated outcomes. Methods We conducted a prospective study of adult RRT reviews over a one month period between 6th June and 10th July 2016 in a large tertiary hospital in Melbourne Australia Results Over a one-month period, there were 282 RRT reviews, 258 of which were included. One hundred out of 258 (38.8%) RRT review patients fulfilled qSOFA criteria. qSOFA positive patients were more likely to be admitted to the intensive care unit (29% vs 18%, P = 0.04), to have repeat RRT reviews (27% vs 13%; p = 0.007) and die in hospital (31% vs 10%, P < 0.001). qSOFA positive patients with suspected infection were more likely to be admitted to the intensive care unit compared to patients with infection alone (37% vs 15%, P = 0.002). Eleven of 42 patients (26%) who had infection and qSOFA died whilst in hospital, compared to 8/55 (15%) of patients with infection alone (P = 0.2). Conclusion Adult patients who are qSOFA positive at the time of their RRT review are at increased risk of in-hospital mortality. The assessment of qSOFA may be a useful triage tool during a RRT review.

Original language	English
Pages (from-to)	13-18
Number of pages	6
Journal	Resuscitation
Volume	122
DOIs	https://doi.org/10.1016/j.resuscitation.2017.11.036
Publication status	Published - Jan 2018

Keywords

Infection
qSOFA
RRT call
Sepsis
SOFA

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10.1016/j.resuscitation.2017.11.036

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LeGuen, M., Ballueer, Y., McKay, R., Eastwood, G., Bellomo, R., Jones, D., The Austin Health RRT qSOFA investigators, Topple, M., McIntyre, T., Taylor, C., Blythe, D., Ryan, B., Ali, N., Jeffcote, T., O’Callahan, S., Kubicki, M., Glassford, N., Tseitkin, B., Ho, T., ... Elsom, C. (2018). Frequency and significance of qSOFA criteria during adult rapid response team reviews: A prospective cohort study. Resuscitation, 122, 13-18. https://doi.org/10.1016/j.resuscitation.2017.11.036

@article{97e49041fa9149e08814c26e51424e13,

title = "Frequency and significance of qSOFA criteria during adult rapid response team reviews: A prospective cohort study",

abstract = "Aim A new definition of sepsis released by an international task-force has introduced the concept of quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA). This study aimed to measure the proportion of patients who fulfilled qSOFA criteria during a Rapid Response Team (RRT) review and to assess their associated outcomes. Methods We conducted a prospective study of adult RRT reviews over a one month period between 6th June and 10th July 2016 in a large tertiary hospital in Melbourne Australia Results Over a one-month period, there were 282 RRT reviews, 258 of which were included. One hundred out of 258 (38.8%) RRT review patients fulfilled qSOFA criteria. qSOFA positive patients were more likely to be admitted to the intensive care unit (29% vs 18%, P = 0.04), to have repeat RRT reviews (27% vs 13%; p = 0.007) and die in hospital (31% vs 10%, P < 0.001). qSOFA positive patients with suspected infection were more likely to be admitted to the intensive care unit compared to patients with infection alone (37% vs 15%, P = 0.002). Eleven of 42 patients (26%) who had infection and qSOFA died whilst in hospital, compared to 8/55 (15%) of patients with infection alone (P = 0.2). Conclusion Adult patients who are qSOFA positive at the time of their RRT review are at increased risk of in-hospital mortality. The assessment of qSOFA may be a useful triage tool during a RRT review.",

keywords = "Infection, qSOFA, RRT call, Sepsis, SOFA",

author = "Maurice LeGuen and Yvonne Ballueer and Richard McKay and Glenn Eastwood and Rinaldo Bellomo and Daryl Jones and {The Austin Health RRT qSOFA investigators} and Michelle Topple and Tammie McIntyre and Carmel Taylor and Damien Blythe and Brooke Ryan and Najeea Ali and Toby Jeffcote and Sadie O{\textquoteright}Callahan and Mark Kubicki and Neil Glassford and Boris Tseitkin and Timothy Ho and Wisam Al-Bassam and Rahul Costa-Pinto and Kelvin Kuik and Scott May and Jeremy Broad and Foo, {Chuan Tai} and Michelle Grigoriadis and James Bennett and Karen McCrohan and Melissa Gloster and Merryn Barker and Mary Larsen and William Tui and Cathy Young and Clair Osborne and Sandra Moore and Brian Shortal and Penny Ashworth and Lisa Fuhrmeister and Craig Lesom and Tony King and Alison Rose and Robyn Best and Kristy Ross and Lyndal Fawcett and Meagan Delaney and Melissa Butterworth and Melisa Bu and Been Cherian and Jayne Ramsdale and Renee Bartlett and Carmel Walsh and Kate Dixon and Abbey Littlepage and Valerie Liambos and Margaret Holley and Catherine Campbell and Deirdre Nion and Michelle Baxter and Mee Cheng and Monica Dowling and Craig Elsom",

year = "2018",

month = jan,

doi = "10.1016/j.resuscitation.2017.11.036",

language = "English",

volume = "122",

pages = "13--18",

journal = "Resuscitation",

issn = "0300-9572",

publisher = "Elsevier BV",

}

LeGuen, M, Ballueer, Y, McKay, R, Eastwood, G, Bellomo, R, Jones, D, The Austin Health RRT qSOFA investigators, Topple, M, McIntyre, T, Taylor, C, Blythe, D, Ryan, B, Ali, N, Jeffcote, T, O’Callahan, S, Kubicki, M, Glassford, N, Tseitkin, B, Ho, T, Al-Bassam, W, Costa-Pinto, R, Kuik, K, May, S, Broad, J, Foo, CT, Grigoriadis, M, Bennett, J, McCrohan, K, Gloster, M, Barker, M, Larsen, M, Tui, W, Young, C, Osborne, C, Moore, S, Shortal, B, Ashworth, P, Fuhrmeister, L, Lesom, C, King, T, Rose, A, Best, R, Ross, K, Fawcett, L, Delaney, M, Butterworth, M, Bu, M, Cherian, B, Ramsdale, J, Bartlett, R, Walsh, C, Dixon, K, Littlepage, A, Liambos, V, Holley, M, Campbell, C, Nion, D, Baxter, M, Cheng, M, Dowling, M & Elsom, C 2018, 'Frequency and significance of qSOFA criteria during adult rapid response team reviews: A prospective cohort study', Resuscitation, vol. 122, pp. 13-18. https://doi.org/10.1016/j.resuscitation.2017.11.036

TY - JOUR

T1 - Frequency and significance of qSOFA criteria during adult rapid response team reviews

T2 - A prospective cohort study

AU - LeGuen, Maurice

AU - Ballueer, Yvonne

AU - McKay, Richard

AU - Eastwood, Glenn

AU - Bellomo, Rinaldo

AU - Jones, Daryl

AU - The Austin Health RRT qSOFA investigators

AU - Topple, Michelle

AU - McIntyre, Tammie

AU - Taylor, Carmel

AU - Blythe, Damien

AU - Ryan, Brooke

AU - Ali, Najeea

AU - Jeffcote, Toby

AU - O’Callahan, Sadie

AU - Kubicki, Mark

AU - Glassford, Neil

AU - Tseitkin, Boris

AU - Ho, Timothy

AU - Al-Bassam, Wisam

AU - Costa-Pinto, Rahul

AU - Kuik, Kelvin

AU - May, Scott

AU - Broad, Jeremy

AU - Foo, Chuan Tai

AU - Grigoriadis, Michelle

AU - Bennett, James

AU - McCrohan, Karen

AU - Gloster, Melissa

AU - Barker, Merryn

AU - Larsen, Mary

AU - Tui, William

AU - Young, Cathy

AU - Osborne, Clair

AU - Moore, Sandra

AU - Shortal, Brian

AU - Ashworth, Penny

AU - Fuhrmeister, Lisa

AU - Lesom, Craig

AU - King, Tony

AU - Rose, Alison

AU - Best, Robyn

AU - Ross, Kristy

AU - Fawcett, Lyndal

AU - Delaney, Meagan

AU - Butterworth, Melissa

AU - Bu, Melisa

AU - Cherian, Been

AU - Ramsdale, Jayne

AU - Bartlett, Renee

AU - Walsh, Carmel

AU - Dixon, Kate

AU - Littlepage, Abbey

AU - Liambos, Valerie

AU - Holley, Margaret

AU - Campbell, Catherine

AU - Nion, Deirdre

AU - Baxter, Michelle

AU - Cheng, Mee

AU - Dowling, Monica

AU - Elsom, Craig

PY - 2018/1

Y1 - 2018/1

N2 - Aim A new definition of sepsis released by an international task-force has introduced the concept of quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA). This study aimed to measure the proportion of patients who fulfilled qSOFA criteria during a Rapid Response Team (RRT) review and to assess their associated outcomes. Methods We conducted a prospective study of adult RRT reviews over a one month period between 6th June and 10th July 2016 in a large tertiary hospital in Melbourne Australia Results Over a one-month period, there were 282 RRT reviews, 258 of which were included. One hundred out of 258 (38.8%) RRT review patients fulfilled qSOFA criteria. qSOFA positive patients were more likely to be admitted to the intensive care unit (29% vs 18%, P = 0.04), to have repeat RRT reviews (27% vs 13%; p = 0.007) and die in hospital (31% vs 10%, P < 0.001). qSOFA positive patients with suspected infection were more likely to be admitted to the intensive care unit compared to patients with infection alone (37% vs 15%, P = 0.002). Eleven of 42 patients (26%) who had infection and qSOFA died whilst in hospital, compared to 8/55 (15%) of patients with infection alone (P = 0.2). Conclusion Adult patients who are qSOFA positive at the time of their RRT review are at increased risk of in-hospital mortality. The assessment of qSOFA may be a useful triage tool during a RRT review.

AB - Aim A new definition of sepsis released by an international task-force has introduced the concept of quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA). This study aimed to measure the proportion of patients who fulfilled qSOFA criteria during a Rapid Response Team (RRT) review and to assess their associated outcomes. Methods We conducted a prospective study of adult RRT reviews over a one month period between 6th June and 10th July 2016 in a large tertiary hospital in Melbourne Australia Results Over a one-month period, there were 282 RRT reviews, 258 of which were included. One hundred out of 258 (38.8%) RRT review patients fulfilled qSOFA criteria. qSOFA positive patients were more likely to be admitted to the intensive care unit (29% vs 18%, P = 0.04), to have repeat RRT reviews (27% vs 13%; p = 0.007) and die in hospital (31% vs 10%, P < 0.001). qSOFA positive patients with suspected infection were more likely to be admitted to the intensive care unit compared to patients with infection alone (37% vs 15%, P = 0.002). Eleven of 42 patients (26%) who had infection and qSOFA died whilst in hospital, compared to 8/55 (15%) of patients with infection alone (P = 0.2). Conclusion Adult patients who are qSOFA positive at the time of their RRT review are at increased risk of in-hospital mortality. The assessment of qSOFA may be a useful triage tool during a RRT review.

KW - Infection

KW - qSOFA

KW - RRT call

KW - Sepsis

KW - SOFA

UR - http://www.scopus.com/inward/record.url?scp=85034057074&partnerID=8YFLogxK

U2 - 10.1016/j.resuscitation.2017.11.036

DO - 10.1016/j.resuscitation.2017.11.036

M3 - Article

C2 - 29133019

AN - SCOPUS:85034057074

SN - 0300-9572

VL - 122

SP - 13

EP - 18

JO - Resuscitation

JF - Resuscitation

ER -

Frequency and significance of qSOFA criteria during adult rapid response team reviews: A prospective cohort study

Abstract

Keywords

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