Frequency and large T (LT) sequence of JC polyomavirus DNA in oligodendrocytes, astrocytes and granular cells in Non-PML brain

Julianne Bayliss, Tanja Jankovic-Karasoulos, Catriona Ann McLean

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Pure populations of astrocytes, oligodendrocytes, CGNs and microglia from frontal cortex and cerebellum of 17 non-PML patients (9 immunocompetent; 8 immunosuppressed) were isolated by laser capture microdissection (LCM). JCV large T (LT) antigen DNA was detected by triple nested polymerase chain reaction (PCR). Sequence analysis was performed to assess LT gene variation. JCV DNA was detected in oligodendrocytes, astrocytes and CGNs of non-PML brains.
Original languageEnglish
Pages (from-to)329 - 336
Number of pages8
JournalBrain Pathology
Issue number3
Publication statusPublished - 2012

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