Fractional flow reserve-guided management in stable coronary disease and acute myocardial infarction: Recent developments

Colin Berry, David Corcoran, Barry Hennigan, Stuart Watkins, Jamie Layland, Keith G. Oldroyd

Research output: Contribution to journalReview ArticleResearchpeer-review

45 Citations (Scopus)


Coronary artery disease (CAD) is a leading global cause of morbidity and mortality, and improvements in the diagnosis and treatment of CAD can reduce the health and economic burden of this condition. Fractional flow reserve (FFR) is an evidence-based diagnostic test of the physiological significance of a coronary artery stenosis. Fractional flow reserve is a pressure-derived index of the maximal achievable myocardial blood flow in the presence of an epicardial coronary stenosis as a ratio to maximum achievable flow if that artery were normal. When compared with standard angiography-guided management, FFR disclosure is impactful on the decision for revascularization and clinical outcomes. In this article, we review recent developments with FFR in patients with stable CAD and recent myocardial infarction. Specifically, we review novel developments in our understanding of CAD pathophysiology, diagnostic applications, prognostic studies, clinical trials, and clinical guidelines.

Original languageEnglish
Pages (from-to)3155-3164c
Number of pages13
JournalEuropean Heart Journal
Issue number45
Publication statusPublished - 1 Dec 2015
Externally publishedYes


  • Fractional flow reserve † Stable angina † Myocardial infarction † Medical therapy † Coronary revascularization

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