FOXL2C134W: much ado about something!

Peter J. Fuller, Trang Nguyen, Maria Alexiadis, Simon Chu

Research output: Contribution to journalComment / DebateOtherpeer-review

2 Citations (Scopus)

Abstract

Recent studies have suggested that the unique FOXL2C134W mutation, which is pathognomonic for adult granulosa cell tumours of the ovary, is a tumour suppressor gene. In a recent issue of The Journal of Pathology, a detailed study by Pilsworth et al seeks to rebut the proposition that the FOXL2C134W mutation, which uniquely characterises adult granulosa cell tumours of the ovary, leads to reduced transcript levels with the implication that FOXL2 is a tumour suppressor gene. The study provides compelling evidence that both wild-type and mutant FOXL2 transcripts and protein are expressed at equivalent levels. In the context of other recent studies, one is drawn to the conclusion that FOXL2C134W is a gain-of-function mutation whose impact is mediated through enhanced interactions with the SMAD transcription factor complex.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalJournal of Pathology
Volume256
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • FOXL2
  • granulosa cells
  • ovarian cancer
  • ovary
  • stromal tumours

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