Four-stage mechanistic model of dynamic platelet aggregation in a microfluidic chip

Miguel E. Combariza, Francisco J. Tovar-Lopez, Warwick S. Nesbitt, Xinghuo Yu, Arnan Mitchell

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

3 Citations (Scopus)

Abstract

Understanding the dynamics of platelet aggregation is fundamental to the formulation of antithrombotic treatments that can reduce morbidity rates associated with cardiovascular diseases. A recent study, supported by a microfluidics platform emulating a thrombogenic stenosis in an environment independent of chemical pathways and under non-recirculating conditions, has revealed the primary role of hemodynamics to initiate platelet aggregation. We identify four distinct stages in the thrombus growth present in such a platform, and formulate an explanatory physical model of the relationship between the hemodynamics and thrombus growth. This model provides insight into the mechanistic variables regulating platelet aggregation.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1564-1566
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 1 Jan 2012
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2012) - Okinawa, Japan
Duration: 28 Oct 20121 Nov 2012
Conference number: 16th

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2012)
Abbreviated titleMicroTAS 2012
CountryJapan
CityOkinawa
Period28/10/121/11/12

Keywords

  • Hemodynamics
  • Mechanistic model
  • Microfluidics
  • Non-recirculating
  • Stenotic flow
  • Thrombus

Cite this

Combariza, M. E., Tovar-Lopez, F. J., Nesbitt, W. S., Yu, X., & Mitchell, A. (2012). Four-stage mechanistic model of dynamic platelet aggregation in a microfluidic chip. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1564-1566). Chemical and Biological Microsystems Society.
Combariza, Miguel E. ; Tovar-Lopez, Francisco J. ; Nesbitt, Warwick S. ; Yu, Xinghuo ; Mitchell, Arnan. / Four-stage mechanistic model of dynamic platelet aggregation in a microfluidic chip. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. pp. 1564-1566
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Combariza, ME, Tovar-Lopez, FJ, Nesbitt, WS, Yu, X & Mitchell, A 2012, Four-stage mechanistic model of dynamic platelet aggregation in a microfluidic chip. in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, pp. 1564-1566, International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2012), Okinawa, Japan, 28/10/12.

Four-stage mechanistic model of dynamic platelet aggregation in a microfluidic chip. / Combariza, Miguel E.; Tovar-Lopez, Francisco J.; Nesbitt, Warwick S.; Yu, Xinghuo; Mitchell, Arnan.

Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. p. 1564-1566.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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AB - Understanding the dynamics of platelet aggregation is fundamental to the formulation of antithrombotic treatments that can reduce morbidity rates associated with cardiovascular diseases. A recent study, supported by a microfluidics platform emulating a thrombogenic stenosis in an environment independent of chemical pathways and under non-recirculating conditions, has revealed the primary role of hemodynamics to initiate platelet aggregation. We identify four distinct stages in the thrombus growth present in such a platform, and formulate an explanatory physical model of the relationship between the hemodynamics and thrombus growth. This model provides insight into the mechanistic variables regulating platelet aggregation.

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Combariza ME, Tovar-Lopez FJ, Nesbitt WS, Yu X, Mitchell A. Four-stage mechanistic model of dynamic platelet aggregation in a microfluidic chip. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society. 2012. p. 1564-1566