TY - JOUR
T1 - Found in translation
T2 - Understanding the biology and behavior of experimental traumatic brain injury
AU - Bondi, Corina O.
AU - Semple, Bridgette D.
AU - Noble-Haeusslein, Linda J.
AU - Osier, Nicole D.
AU - Carlson, Shaun W.
AU - Dixon, C. Edward
AU - Giza, Christopher C.
AU - Kline, Anthony E.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided.
AB - The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided.
KW - Attentional set-shifting test (AST)
KW - Closed head injury
KW - Concussion
KW - Controlled cortical impact (CCI)
KW - Environmental enrichment (EE)
KW - Fluid percussion (FP)
KW - Neurorehabilitation
KW - Pediatrics
KW - Social behavior
UR - http://www.scopus.com/inward/record.url?scp=84949536000&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2014.12.004
DO - 10.1016/j.neubiorev.2014.12.004
M3 - Review Article
C2 - 25496906
AN - SCOPUS:84949536000
VL - 58
SP - 123
EP - 146
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -