Found in translation: Understanding the biology and behavior of experimental traumatic brain injury

Corina O. Bondi, Bridgette D. Semple, Linda J. Noble-Haeusslein, Nicole D. Osier, Shaun W. Carlson, C. Edward Dixon, Christopher C. Giza, Anthony E. Kline

Research output: Contribution to journalReview ArticleResearchpeer-review

71 Citations (Scopus)

Abstract

The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided.

Original languageEnglish
Pages (from-to)123-146
Number of pages24
JournalNeuroscience and Biobehavioral Reviews
Volume58
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

Keywords

  • Attentional set-shifting test (AST)
  • Closed head injury
  • Concussion
  • Controlled cortical impact (CCI)
  • Environmental enrichment (EE)
  • Fluid percussion (FP)
  • Neurorehabilitation
  • Pediatrics
  • Social behavior

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