Forward mandibular positioning up-regulates SOX9 and type II collagen expression in the glenoid fossa

A. B.M. Rabie, T. T. She, V. R. Harley

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Regulatory factors governing the formation of bone in the glenoid fossa in response to functional appliance therapy have not been identified. Therefore, the purpose of this study was to investigate the temporal pattern of expression of two key chondrogenesis markers - SOX9 and its target gene, type II collagen - in the glenoid fossa by immunostaining in a 35-day-old Sprague Dawley rat model during both natural growth and forward mandibular positioning. The expression of both factors was up-regulated when the mandible was positioned forward, indicating an enhancement of chondrocyte differentiation and chondroid matrix formation. Our results indicate that chondroid bone formation in the glenoid fossa in response to forward mandibular positioning is regulated by molecular markers indicative of endochondral ossification.

Original languageEnglish
Pages (from-to)725-730
Number of pages6
JournalJournal of Dental Research
Issue number9
Publication statusPublished - 1 Jan 2003
Externally publishedYes


  • Forward mandibular positioning
  • Glenoid fossa
  • SOX9
  • Type II collagen

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